Aim of study is the determination of concentrations of two important cytokines: TNF alfa and IL-8 in children with bacterial meningitis to establish a correlation between infection, CSF concentration of cytokines and neurological sequelae. TNF alfa and IL-8 concentrations in CSF have been measured by quantitative immunometric enzyme assay during the course of the disease. In the purulent meningitis we observed that CSF concentrations of these cytokines decreased to undetectable values 24 to 48 hours after beginning of the antibiotic therapy. Conversely, in the 3 patients with mycobacterial meningitis (TBM) the concentrations of IL-8 were higher for a longer period, being detectable in the CSF between 4 and 8 weeks after the beginning of the specific treatment. We found no significant differences of the values of IL-8 in children with neurological sequelae compared with children without sequelae.
|Translated title of the contribution||Bacterial meningitis and CSF cytokines|
|Number of pages||4|
|Journal||Infezioni in Medicina|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Microbiology (medical)