Abstract
Many bacteria causing persistent infections produce toxins whose mechanisms of action indicate that they could have a role in carcinogenesis. Some toxins, like CDT and colibactin, directly attack the genome by damaging DNA whereas others, as for example CNF1, CagA and BFT, impinge on key eukaryotic processes, such as cellular signalling and cell death. These bacterial toxins, together with other less known toxins, mimic carcinogens and tumour promoters. The aim of this review is to fulfil an up-to-date analysis of toxins with carcinogenic potential that have been already correlated to human cancers. Bacterial toxins-induced carcinogenesis represents an emerging aspect in bacteriology, and its significance is increasingly recognized.
| Original language | English |
|---|---|
| Article number | ftv105 |
| Journal | Pathogens and Disease |
| Volume | 74 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 1 2018 |
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Keywords
- Bacterial toxins
- Cancer
- Cell signalling
- Cell survival
- DNA damage
- Microbiota
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology and Microbiology(all)
- Microbiology (medical)
- Infectious Diseases
Cite this
Bacterial protein toxins in human cancers. / Rosadi, Francesca; Fiorentini, Carla; Fabbri, Alessia.
In: Pathogens and Disease, Vol. 74, No. 1, ftv105, 01.02.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Bacterial protein toxins in human cancers
AU - Rosadi, Francesca
AU - Fiorentini, Carla
AU - Fabbri, Alessia
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Many bacteria causing persistent infections produce toxins whose mechanisms of action indicate that they could have a role in carcinogenesis. Some toxins, like CDT and colibactin, directly attack the genome by damaging DNA whereas others, as for example CNF1, CagA and BFT, impinge on key eukaryotic processes, such as cellular signalling and cell death. These bacterial toxins, together with other less known toxins, mimic carcinogens and tumour promoters. The aim of this review is to fulfil an up-to-date analysis of toxins with carcinogenic potential that have been already correlated to human cancers. Bacterial toxins-induced carcinogenesis represents an emerging aspect in bacteriology, and its significance is increasingly recognized.
AB - Many bacteria causing persistent infections produce toxins whose mechanisms of action indicate that they could have a role in carcinogenesis. Some toxins, like CDT and colibactin, directly attack the genome by damaging DNA whereas others, as for example CNF1, CagA and BFT, impinge on key eukaryotic processes, such as cellular signalling and cell death. These bacterial toxins, together with other less known toxins, mimic carcinogens and tumour promoters. The aim of this review is to fulfil an up-to-date analysis of toxins with carcinogenic potential that have been already correlated to human cancers. Bacterial toxins-induced carcinogenesis represents an emerging aspect in bacteriology, and its significance is increasingly recognized.
KW - Bacterial toxins
KW - Cancer
KW - Cell signalling
KW - Cell survival
KW - DNA damage
KW - Microbiota
UR - http://www.scopus.com/inward/record.url?scp=84989177721&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989177721&partnerID=8YFLogxK
U2 - 10.1093/femspd/ftv105
DO - 10.1093/femspd/ftv105
M3 - Review article
C2 - 26534910
AN - SCOPUS:84989177721
VL - 74
JO - Pathogens and Disease
JF - Pathogens and Disease
SN - 2049-632X
IS - 1
M1 - ftv105
ER -