Bacterial protein toxins in human cancers

Francesca Rosadi, Carla Fiorentini, Alessia Fabbri

Research output: Contribution to journalReview article

Abstract

Many bacteria causing persistent infections produce toxins whose mechanisms of action indicate that they could have a role in carcinogenesis. Some toxins, like CDT and colibactin, directly attack the genome by damaging DNA whereas others, as for example CNF1, CagA and BFT, impinge on key eukaryotic processes, such as cellular signalling and cell death. These bacterial toxins, together with other less known toxins, mimic carcinogens and tumour promoters. The aim of this review is to fulfil an up-to-date analysis of toxins with carcinogenic potential that have been already correlated to human cancers. Bacterial toxins-induced carcinogenesis represents an emerging aspect in bacteriology, and its significance is increasingly recognized.

Original languageEnglish
Article numberftv105
JournalPathogens and Disease
Volume74
Issue number1
DOIs
Publication statusPublished - Feb 1 2018

Keywords

  • Bacterial toxins
  • Cancer
  • Cell signalling
  • Cell survival
  • DNA damage
  • Microbiota

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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