Bacterial toxins and the Rho GTP-binding protein: What microbes teach us about cell regulation

Carla Florentini, Michel Gauthier, Gianfranco Donelli, Patrice Boquet

Research output: Contribution to journalArticlepeer-review

Abstract

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

Original languageEnglish
Pages (from-to)720-728
Number of pages9
JournalCell Death and Differentiation
Volume5
Issue number9
Publication statusPublished - Sep 1998

Keywords

  • C3
  • Cell regulation
  • CNF1
  • Rho

ASJC Scopus subject areas

  • Cell Biology

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