Bactericidal activity of levofloxacin, gatifloxacin, penicillin, meropenem and rokitamycin against Bacillus anthracis clinical isolates

Lorenzo Drago, Elena De Vecchi, Alessandra Lombardi, Lucia Nicola, Marilena Valli, Maria Rita Gismondo

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to evaluate the bactericidal rates of levofloxacin, gatifloxacin, penicillin, meropenem and rokitamycin against seven isolates of Bacillus anthracis clinically isolated between 1960 and 1970. After determination of MIC and MBC, time-kill experiments were carried out. Antimicrobial activity was evaluated at concentrations equal to 1 x, 2 x, 4 x and 8 x MIC after 0, 3, 6, 12 and 24 h of incubation with the drugs. Bactericidal activity was defined as a decrease in bacterial count of at least 3 log10. All the isolates were susceptible to all the antibiotics, by considering the antistaphylococcal breakpoints. Levofloxacin was bactericidal at 1 x MIC after 24 h and at 4 x MIC after 12 h, and gatifloxacin was bactericidal at 2 x MIC after 24 h and at 8 x MIC after 12 h. Meropenem, rokitamycin and penicillin also showed bactericidal activity at concentrations of 4 x and 8 x MIC, respectively, but only after 24 h incubation; after the same time, meropenem and rokitamycin showed a more marked killing than penicillin at 2 x MIC.

Original languageEnglish
Pages (from-to)1059-1063
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume50
Issue number6
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Anthrax
  • Bacillus anthracis
  • Fluoroquinolones
  • In vitro susceptibility testing
  • Macrolides
  • Meropenem
  • Penicillin
  • Rokitamycin

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

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