Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori

Piero Marone, L. Bono, E. Leone, S. Bona, E. Carretto, L. Perversi

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we evaluated the antibacterial activity of mastic gum, a resin obtained from the Pistacia lentiscus tree, against clinical isolates of Helicobacter pylori. The minimal bactericidal concentrations (MBCs) were obtained by a microdilution assay. Mastic gum killed 50% of the strains tested at a concentration of 125 μg/ml and 90% at a concentration of 500 μg/ml. The influence of sub-MBCs of mastic gum on the morphologies of H. pylori was evaluated by transmission electron microscopy. The lentiscus resin induced blebbing, morphological abnormalities and cellular fragmentation in H. pylori cells.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalJournal of Chemotherapy
Volume13
Issue number6
Publication statusPublished - 2001

Keywords

  • Antibacterial activity
  • Electron microscopy
  • Helicobacter pylori
  • Mastic gum
  • Pistacia lentiscus

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Microbiology (medical)

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