BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria

Monica Bortolin, Carlo L. Romanò, Alessandro Bidossi, Elena De Vecchi, Roberto Mattina, Lorenzo Drago

Research output: Contribution to journalArticle

Abstract

Aim: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. Materials & methods: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. Results: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis. Conclusion: BAG-S53P4 is a suitable bone substitute that can be used as an extender with autologous bone graft to promote better fusion and healing.

Original languageEnglish
Pages (from-to)525-533
Number of pages9
JournalFuture Microbiology
Volume13
Issue number5
DOIs
Publication statusPublished - Apr 1 2018

Keywords

  • antimicrobial activity
  • BAG-S53P4
  • bioactive glass
  • bone and joint infections
  • bone graft
  • Enterobacteriaceae
  • gentamicin
  • MRSA
  • MRSE
  • vancomycin

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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