BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria

Monica Bortolin; Carlo L. Romanò; Alessandro Bidossi; Elena De Vecchi; Roberto Mattina; Lorenzo Drago

doi:10.2217/fmb-2016-0171

BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria

Monica Bortolin, Carlo L. Romanò, Alessandro Bidossi, Elena De Vecchi, Roberto Mattina, Lorenzo Drago

IRCCS Istituto Ortopedico Galeazzi

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. Materials & methods: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. Results: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis. Conclusion: BAG-S53P4 is a suitable bone substitute that can be used as an extender with autologous bone graft to promote better fusion and healing.

Original language	English
Pages (from-to)	525-533
Number of pages	9
Journal	Future Microbiology
Volume	13
Issue number	5
DOIs	https://doi.org/10.2217/fmb-2016-0171
Publication status	Published - Apr 1 2018

Keywords

antimicrobial activity
BAG-S53P4
bioactive glass
bone and joint infections
bone graft
Enterobacteriaceae
gentamicin
MRSA
MRSE
vancomycin

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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title = "BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria",

abstract = "Aim: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. Materials & methods: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. Results: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis. Conclusion: BAG-S53P4 is a suitable bone substitute that can be used as an extender with autologous bone graft to promote better fusion and healing.",

keywords = "antimicrobial activity, BAG-S53P4, bioactive glass, bone and joint infections, bone graft, Enterobacteriaceae, gentamicin, MRSA, MRSE, vancomycin",

author = "Monica Bortolin and Roman{\`o}, {Carlo L.} and Alessandro Bidossi and {De Vecchi}, Elena and Roberto Mattina and Lorenzo Drago",

year = "2018",

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doi = "10.2217/fmb-2016-0171",

language = "English",

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journal = "Future Microbiology",

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T1 - BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria

AU - Bortolin, Monica

AU - Romanò, Carlo L.

AU - Bidossi, Alessandro

AU - De Vecchi, Elena

AU - Mattina, Roberto

AU - Drago, Lorenzo

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Aim: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. Materials & methods: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. Results: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis. Conclusion: BAG-S53P4 is a suitable bone substitute that can be used as an extender with autologous bone graft to promote better fusion and healing.

AB - Aim: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. Materials & methods: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. Results: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis. Conclusion: BAG-S53P4 is a suitable bone substitute that can be used as an extender with autologous bone graft to promote better fusion and healing.

KW - antimicrobial activity

KW - BAG-S53P4

KW - bioactive glass

KW - bone and joint infections

KW - bone graft

KW - Enterobacteriaceae

KW - gentamicin

KW - MRSA

KW - MRSE

KW - vancomycin

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JO - Future Microbiology

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SN - 1746-0913

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ER -

BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria

Abstract

Keywords

ASJC Scopus subject areas

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