Abstract
Aim: To evaluate the suitability of bioactive glass (BAG)-S53P4 as a bone-graft extender for large bony defect filling in bone and joint infection. Materials & methods: Antimicrobial activity of BAG-S53P4 against clinically relevant strains isolated from bone and joint infections was evaluated by means of time-kill curves in presence of bone graft. Furthermore, the susceptibility to BAG of strains resistant to vancomycin and gentamicin was assessed. Results: Though attenuated, BAG maintains a good in vitro antimicrobial activity in presence of human body fluids and tissues contained in bone graft, with the exception of Enterococcus faecalis. Conclusion: BAG-S53P4 is a suitable bone substitute that can be used as an extender with autologous bone graft to promote better fusion and healing.
Original language | English |
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Pages (from-to) | 525-533 |
Number of pages | 9 |
Journal | Future Microbiology |
Volume | 13 |
Issue number | 5 |
DOIs | |
Publication status | Published - Apr 1 2018 |
Keywords
- antimicrobial activity
- BAG-S53P4
- bioactive glass
- bone and joint infections
- bone graft
- Enterobacteriaceae
- gentamicin
- MRSA
- MRSE
- vancomycin
ASJC Scopus subject areas
- Microbiology
- Microbiology (medical)