BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for alzheimer's disease

Eliana Venturelli, Chiara Fenoglio, Francesca Clerici, Alessandra Marcone, Luisa Benussi, Roberta Ghidoni, Salvatore Gallone, Francesca Cortini, Maria Serpente, Claudia Cantoni, Giorgio Fumagalli, Elisa Ridolfi, Stefano Cappa, Giuliano Binetti, Massimo Franceschi, Innocenzo Rainero, Maria Teresa Giordana, Claudio Mariani, Nereo Bresolin, Elio Scarpini

Research output: Contribution to journalArticle

Abstract

BCL2-associated athanogene 1 (BAG1) is an anti-apoptotic factor that interacts with tau and regulates its proteasomal degradation. A significant increase of the BAG-1M isoform was found in Alzheimer's disease (AD) brains, and the protein co-localized with tau and amyloid. We carried out an association study of BAG1 in a population of 291 patients clinically diagnosed with frontotemporal lobar degeneration (FTLD), none of whom was a carrier of mutations in progranulin or microtubule associated protein tau genes and 374 with AD as compared with 314 age-and gender-matched controls. In addition, another candidate named Chromatin-modifying protein 5 (CHMP5) and located in the same linkage disequilibrium block, has been included in this study. The distribution of the two single nucleotide polymorphism (SNPs), rs844239 in CHMP5 and rs706118 in BAG1, covering 100% gene variability, were determined. A statistically significant decreased allelic frequency of the BAG-1 rs706118 SNP was observed in patients with FTLD as compared with controls (16.7 versus 23.9%; p = 0.007, OR: 0.35, CI: 0.25-0.50), whereas allelic frequency of the SNP in patients with AD was similar to controls (24.3%, p > 0.05). Conversely, no significant association was found as regards CHMP5 rs844239. Stratifying according to gender, no differences were observed. BAG-1 rs706118 SNP likely acts as protective factor for sporadic FTLD, but not for AD, suggesting its specific role in a pathogenic event in FTLD. Nevertheless, a replication study would be needed to confirm these preliminary results.

Original languageEnglish
Pages (from-to)701-707
Number of pages7
JournalJournal of Alzheimer's Disease
Volume23
Issue number4
DOIs
Publication statusPublished - 2011

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Keywords

  • Alzheimer's disease
  • BAG1
  • CHMP5
  • frontotemporal lobar degeneration
  • neurodegeneration
  • polymorphism
  • risk factor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Venturelli, E., Fenoglio, C., Clerici, F., Marcone, A., Benussi, L., Ghidoni, R., Gallone, S., Cortini, F., Serpente, M., Cantoni, C., Fumagalli, G., Ridolfi, E., Cappa, S., Binetti, G., Franceschi, M., Rainero, I., Giordana, M. T., Mariani, C., Bresolin, N., & Scarpini, E. (2011). BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for alzheimer's disease. Journal of Alzheimer's Disease, 23(4), 701-707. https://doi.org/10.3233/JAD-2010-101416