Balance deficit with opened or closed eyes reveals involvement of different structures of the central nervous system in multiple sclerosis

Luca Prosperini, Nikolaos Petsas, Eytan Raz, Emilia Sbardella, Francesca Tona, Chiara Rosa Mancinelli, Carlo Pozzilli, Patrizia Pantano

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate whether balance deficit in patients with multiple sclerosis (MS), as assessed with eyes opened (EO) and closed (EC), is associated with damage of different structures of the central nervous system (CNS). Methods: Fifty patients with MS and 20 healthy controls (HCs) underwent static posturography to calculate the body's center of pressure displacement (COP path) with EO and EC. They were scanned using a 3.0T magnet to obtain PD/T2 and 3D-T1-weighted images of the brain and spinal cord. We determined the mid-sagittal cerebellum area (MSCA) and upper cervical cord cross-sectional area (UCCA). We also measured the patients' lesion volumes (T2-LVs) on the whole brain and at different infratentorial levels. Results: MS patients had wider COP paths with both EO and EC (p 0.001), and lower values in both MSCA (p = 0.01) and UCCA (p = 0.008) than HCs. The COP path with EO was associated with MSCA (Beta = - 0.58; p = 0.004) and T2- LV on middle cerebellar peduncles (Beta = 0.59; p = 0.002). The COP path with EC was associated with UCCA (Beta= - 22.74; p = 0.003) and brainstem T2-LV (Beta = 0.52; p = 0.01). Conclusions: Balance deficit in MS was related to atrophy of both the cerebellum and spinal cord, but the extent of COP path under the two different conditions (EO or EC) implied different patterns of damage in the CNS.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalMultiple Sclerosis Journal
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Balance
  • center of pressure displacement
  • disability
  • lesions
  • magnetic resonance imaging
  • multiple sclerosis
  • posturography
  • vision

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Balance deficit with opened or closed eyes reveals involvement of different structures of the central nervous system in multiple sclerosis'. Together they form a unique fingerprint.

Cite this