TY - JOUR
T1 - Balancing donor and recipient risk factors in liver transplantation
T2 - The value of D-MELD with particular reference to HCV recipients
AU - Avolio, A. W.
AU - Cillo, U.
AU - Salizzoni, M.
AU - De Carlis, L.
AU - Colledan, M.
AU - Gerunda, G. E.
AU - Mazzaferro, V.
AU - Tisone, G.
AU - Romagnoli, R.
AU - Caccamo, L.
AU - Rossi, M.
AU - Vitale, A.
AU - Cucchetti, A.
AU - Lupo, L.
AU - Gruttadauria, S.
AU - Nicolotti, N.
AU - Burra, P.
AU - Gasbarrini, A.
AU - Agnes, S.
AU - Avolio, A. W.
AU - Agnes, S.
AU - Lirosi, M. C.
AU - Gasbarrini, A.
AU - Miele, L.
AU - Pompili, M.
AU - Siciliano, M.
AU - Perilli, V.
AU - Gaspari, R.
AU - Castagneto, M.
AU - Salizzoni, M.
AU - Romagnoli, R.
AU - Lupo, F.
AU - Tandoi, F.
AU - De Carlis, L.
AU - Mangoni, I.
AU - Belli, L.
AU - Pinna, A. D.
AU - Cucchetti, A.
AU - Cescon, M.
AU - Gridelli, B.
AU - Gruttadauria, S.
AU - Li Petri, S.
AU - Volpes, R.
AU - Colledan, M.
AU - Pinelli, D.
AU - Fagiuoli, S.
AU - Mazzaferro, V.
AU - Regalia, E.
AU - Dalle Ore, G.
AU - De Ville De Goyet, J.
AU - On behalf of the Donor-to-Recipient Italian Liver Transplant (D2R-ILTx) Study Group
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival 1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5 yrs PS
AB - Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival 1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5 yrs PS
KW - D-MELD
KW - donor-recipient match
KW - liver transplantation
KW - outcome
KW - prognosis
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=82455212065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82455212065&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2011.03732.x
DO - 10.1111/j.1600-6143.2011.03732.x
M3 - Article
C2 - 21920017
AN - SCOPUS:82455212065
VL - 11
SP - 2724
EP - 2736
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 12
ER -