Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients

Raffaele Marfella, Michelangela Barbieri, Roberto Ruggiero, Maria Rosaria Rizzo, Rodolfo Grella, Anna Licia Mozzillo, Ludovico Docimo, Giuseppe Paolisso

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE - We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. RESEARCH DESIGN AND METHODS - The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured. RESULTS - Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P <0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P <0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P <0.01). CONCLUSIONS - Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.

Original languageEnglish
Pages (from-to)287-289
Number of pages3
JournalDiabetes Care
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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