Abstract
OBJECTIVE - We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. RESEARCH DESIGN AND METHODS - The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured. RESULTS - Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P <0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P <0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P <0.01). CONCLUSIONS - Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.
| Original language | English |
|---|---|
| Pages (from-to) | 287-289 |
| Number of pages | 3 |
| Journal | Diabetes Care |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
Fingerprint
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialised Nursing
Cite this
Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients. / Marfella, Raffaele; Barbieri, Michelangela; Ruggiero, Roberto; Rizzo, Maria Rosaria; Grella, Rodolfo; Mozzillo, Anna Licia; Docimo, Ludovico; Paolisso, Giuseppe.
In: Diabetes Care, Vol. 33, No. 2, 02.2010, p. 287-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients
AU - Marfella, Raffaele
AU - Barbieri, Michelangela
AU - Ruggiero, Roberto
AU - Rizzo, Maria Rosaria
AU - Grella, Rodolfo
AU - Mozzillo, Anna Licia
AU - Docimo, Ludovico
AU - Paolisso, Giuseppe
PY - 2010/2
Y1 - 2010/2
N2 - OBJECTIVE - We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. RESEARCH DESIGN AND METHODS - The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured. RESULTS - Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P <0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P <0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P <0.01). CONCLUSIONS - Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.
AB - OBJECTIVE - We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. RESEARCH DESIGN AND METHODS - The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured. RESULTS - Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P <0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P <0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P <0.01). CONCLUSIONS - Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.
UR - http://www.scopus.com/inward/record.url?scp=75149165714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149165714&partnerID=8YFLogxK
U2 - 10.2337/dc09-1343
DO - 10.2337/dc09-1343
M3 - Article
C2 - 19889803
AN - SCOPUS:75149165714
VL - 33
SP - 287
EP - 289
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 2
ER -