TY - JOUR
T1 - Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients
AU - Marfella, Raffaele
AU - Barbieri, Michelangela
AU - Ruggiero, Roberto
AU - Rizzo, Maria Rosaria
AU - Grella, Rodolfo
AU - Mozzillo, Anna Licia
AU - Docimo, Ludovico
AU - Paolisso, Giuseppe
PY - 2010/2
Y1 - 2010/2
N2 - OBJECTIVE - We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. RESEARCH DESIGN AND METHODS - The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured. RESULTS - Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P <0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P <0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P <0.01). CONCLUSIONS - Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.
AB - OBJECTIVE - We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. RESEARCH DESIGN AND METHODS - The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured. RESULTS - Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P <0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P <0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P <0.01). CONCLUSIONS - Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.
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U2 - 10.2337/dc09-1343
DO - 10.2337/dc09-1343
M3 - Article
C2 - 19889803
AN - SCOPUS:75149165714
VL - 33
SP - 287
EP - 289
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 2
ER -