Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients

Raffaele Marfella, Michelangela Barbieri, Roberto Ruggiero, Maria Rosaria Rizzo, Rodolfo Grella, Anna Licia Mozzillo, Ludovico Docimo, Giuseppe Paolisso

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - We evaluated the efficacy of malabsorptive bariatric surgery on daily blood glucose fluctuations and oxidative stress in type 2 diabetic obese patients. RESEARCH DESIGN AND METHODS - The 48-h continuous subcutaneous glucose monitoring was assessed in type 2 diabetic patients before and 1 month after biliopancreatic diversion (BPD) (n = 36), or after diet-induced equivalent weight loss (n = 20). The mean amplitude of glycemic excursions and oxidative stress (nitrotyrosine) were evaluated during continuous subcutaneous glucose monitoring. During a standardized meal, glucagon-like peptide (GLP)-1, glucagon, and insulin were measured. RESULTS - Fasting and postprandial glucose decreased equally in surgical and diet groups. A marked increase in GLP-1 occurred during the interprandial period in surgical patients toward the diet group (P <0.01). Glucagon was more suppressed during the interprandial period in surgical patients compared with the diet group (P <0.01). Mean amplitude of glycemic excursions and nitrotyrosine levels decreased more after BPD than after diet (P <0.01). CONCLUSIONS - Oxidative stress reduction after biliopancreatic diversion seems to be related to the regulation of glucose fluctuations resulting from intestinal bypass.

Original languageEnglish
Pages (from-to)287-289
Number of pages3
JournalDiabetes Care
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2010

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Bariatric Surgery
Biliopancreatic Diversion
Oxidative Stress
Diet
Glucose
Glucagon-Like Peptide 1
Glucagon
Jejunoileal Bypass
Meals
Blood Glucose
Weight Loss
Fasting
Research Design
Insulin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Marfella, R., Barbieri, M., Ruggiero, R., Rizzo, M. R., Grella, R., Mozzillo, A. L., ... Paolisso, G. (2010). Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients. Diabetes Care, 33(2), 287-289. https://doi.org/10.2337/dc09-1343

Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients. / Marfella, Raffaele; Barbieri, Michelangela; Ruggiero, Roberto; Rizzo, Maria Rosaria; Grella, Rodolfo; Mozzillo, Anna Licia; Docimo, Ludovico; Paolisso, Giuseppe.

In: Diabetes Care, Vol. 33, No. 2, 02.2010, p. 287-289.

Research output: Contribution to journalArticle

Marfella, R, Barbieri, M, Ruggiero, R, Rizzo, MR, Grella, R, Mozzillo, AL, Docimo, L & Paolisso, G 2010, 'Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients', Diabetes Care, vol. 33, no. 2, pp. 287-289. https://doi.org/10.2337/dc09-1343
Marfella, Raffaele ; Barbieri, Michelangela ; Ruggiero, Roberto ; Rizzo, Maria Rosaria ; Grella, Rodolfo ; Mozzillo, Anna Licia ; Docimo, Ludovico ; Paolisso, Giuseppe. / Bariatric surgery reduces oxidative stress by blunting 24-h acute glucose fluctuations in type 2 diabetic obese patients. In: Diabetes Care. 2010 ; Vol. 33, No. 2. pp. 287-289.
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