Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: The relevance of hepatic venous pressure gradient

Simonetta Genovesi, Daniela M. Prata Pizzala, Massimo Pozzi, Laura Ratti, Maria Milanese, Antonio Vincenti, Andrea Stella, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

Background: Autonomic dysfunction has been reported as one of the complications of cirrhosis. Aims:: The aim of this study was to test autonomic dysfunction in cirrhotic patients by analysing the baroreflex sensitivity and the baroreceptor effectiveness index (BEI), in order to determine its correlation with the severity and the aetiology of liver disease. Moreover, we explored the relationship between baroreceptor function and mortality in our cohort of patients. Methods:: Clinical and laboratory evaluation, hepatic venous pressure gradient (HVPG) and haemodynamic setting and baroreceptor function were assessed in 45 cirrhotic patients (median age 55, range 38-72 years) divided in groups according to the severity of their disease (26 patients Child A, 13 patients Child B and six patients Child C). Results:: Baroreceptor sensitivity and BEI were impaired in more advanced cirrhotic patients compared with subjects with milder disease (P

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalLiver International
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Baroreceptor effectiveness index
  • Baroreceptor sensitivity
  • Cirrhosis
  • Hepatic venous pressure gradient

ASJC Scopus subject areas

  • Hepatology

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    Genovesi, S., Prata Pizzala, D. M., Pozzi, M., Ratti, L., Milanese, M., Vincenti, A., Stella, A., & Mancia, G. (2010). Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: The relevance of hepatic venous pressure gradient. Liver International, 30(2), 232-239. https://doi.org/10.1111/j.1478-3231.2009.02125.x