Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: The relevance of hepatic venous pressure gradient

Simonetta Genovesi, Daniela M. Prata Pizzala, Massimo Pozzi, Laura Ratti, Maria Milanese, Antonio Vincenti, Andrea Stella, Giuseppe Mancia

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Autonomic dysfunction has been reported as one of the complications of cirrhosis. Aims:: The aim of this study was to test autonomic dysfunction in cirrhotic patients by analysing the baroreflex sensitivity and the baroreceptor effectiveness index (BEI), in order to determine its correlation with the severity and the aetiology of liver disease. Moreover, we explored the relationship between baroreceptor function and mortality in our cohort of patients. Methods:: Clinical and laboratory evaluation, hepatic venous pressure gradient (HVPG) and haemodynamic setting and baroreceptor function were assessed in 45 cirrhotic patients (median age 55, range 38-72 years) divided in groups according to the severity of their disease (26 patients Child A, 13 patients Child B and six patients Child C). Results:: Baroreceptor sensitivity and BEI were impaired in more advanced cirrhotic patients compared with subjects with milder disease (P

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalLiver International
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Pressoreceptors
Venous Pressure
Fibrosis
Liver
Baroreflex
Liver Diseases
Hemodynamics
Mortality

Keywords

  • Baroreceptor effectiveness index
  • Baroreceptor sensitivity
  • Cirrhosis
  • Hepatic venous pressure gradient

ASJC Scopus subject areas

  • Hepatology

Cite this

Genovesi, S., Prata Pizzala, D. M., Pozzi, M., Ratti, L., Milanese, M., Vincenti, A., ... Mancia, G. (2010). Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: The relevance of hepatic venous pressure gradient. Liver International, 30(2), 232-239. https://doi.org/10.1111/j.1478-3231.2009.02125.x

Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis : The relevance of hepatic venous pressure gradient. / Genovesi, Simonetta; Prata Pizzala, Daniela M.; Pozzi, Massimo; Ratti, Laura; Milanese, Maria; Vincenti, Antonio; Stella, Andrea; Mancia, Giuseppe.

In: Liver International, Vol. 30, No. 2, 02.2010, p. 232-239.

Research output: Contribution to journalArticle

Genovesi, S, Prata Pizzala, DM, Pozzi, M, Ratti, L, Milanese, M, Vincenti, A, Stella, A & Mancia, G 2010, 'Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: The relevance of hepatic venous pressure gradient', Liver International, vol. 30, no. 2, pp. 232-239. https://doi.org/10.1111/j.1478-3231.2009.02125.x
Genovesi, Simonetta ; Prata Pizzala, Daniela M. ; Pozzi, Massimo ; Ratti, Laura ; Milanese, Maria ; Vincenti, Antonio ; Stella, Andrea ; Mancia, Giuseppe. / Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis : The relevance of hepatic venous pressure gradient. In: Liver International. 2010 ; Vol. 30, No. 2. pp. 232-239.
@article{fe1385e3a494444886cea3a74535a0e6,
title = "Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: The relevance of hepatic venous pressure gradient",
abstract = "Background: Autonomic dysfunction has been reported as one of the complications of cirrhosis. Aims:: The aim of this study was to test autonomic dysfunction in cirrhotic patients by analysing the baroreflex sensitivity and the baroreceptor effectiveness index (BEI), in order to determine its correlation with the severity and the aetiology of liver disease. Moreover, we explored the relationship between baroreceptor function and mortality in our cohort of patients. Methods:: Clinical and laboratory evaluation, hepatic venous pressure gradient (HVPG) and haemodynamic setting and baroreceptor function were assessed in 45 cirrhotic patients (median age 55, range 38-72 years) divided in groups according to the severity of their disease (26 patients Child A, 13 patients Child B and six patients Child C). Results:: Baroreceptor sensitivity and BEI were impaired in more advanced cirrhotic patients compared with subjects with milder disease (P",
keywords = "Baroreceptor effectiveness index, Baroreceptor sensitivity, Cirrhosis, Hepatic venous pressure gradient",
author = "Simonetta Genovesi and {Prata Pizzala}, {Daniela M.} and Massimo Pozzi and Laura Ratti and Maria Milanese and Antonio Vincenti and Andrea Stella and Giuseppe Mancia",
year = "2010",
month = "2",
doi = "10.1111/j.1478-3231.2009.02125.x",
language = "English",
volume = "30",
pages = "232--239",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

TY - JOUR

T1 - Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis

T2 - The relevance of hepatic venous pressure gradient

AU - Genovesi, Simonetta

AU - Prata Pizzala, Daniela M.

AU - Pozzi, Massimo

AU - Ratti, Laura

AU - Milanese, Maria

AU - Vincenti, Antonio

AU - Stella, Andrea

AU - Mancia, Giuseppe

PY - 2010/2

Y1 - 2010/2

N2 - Background: Autonomic dysfunction has been reported as one of the complications of cirrhosis. Aims:: The aim of this study was to test autonomic dysfunction in cirrhotic patients by analysing the baroreflex sensitivity and the baroreceptor effectiveness index (BEI), in order to determine its correlation with the severity and the aetiology of liver disease. Moreover, we explored the relationship between baroreceptor function and mortality in our cohort of patients. Methods:: Clinical and laboratory evaluation, hepatic venous pressure gradient (HVPG) and haemodynamic setting and baroreceptor function were assessed in 45 cirrhotic patients (median age 55, range 38-72 years) divided in groups according to the severity of their disease (26 patients Child A, 13 patients Child B and six patients Child C). Results:: Baroreceptor sensitivity and BEI were impaired in more advanced cirrhotic patients compared with subjects with milder disease (P

AB - Background: Autonomic dysfunction has been reported as one of the complications of cirrhosis. Aims:: The aim of this study was to test autonomic dysfunction in cirrhotic patients by analysing the baroreflex sensitivity and the baroreceptor effectiveness index (BEI), in order to determine its correlation with the severity and the aetiology of liver disease. Moreover, we explored the relationship between baroreceptor function and mortality in our cohort of patients. Methods:: Clinical and laboratory evaluation, hepatic venous pressure gradient (HVPG) and haemodynamic setting and baroreceptor function were assessed in 45 cirrhotic patients (median age 55, range 38-72 years) divided in groups according to the severity of their disease (26 patients Child A, 13 patients Child B and six patients Child C). Results:: Baroreceptor sensitivity and BEI were impaired in more advanced cirrhotic patients compared with subjects with milder disease (P

KW - Baroreceptor effectiveness index

KW - Baroreceptor sensitivity

KW - Cirrhosis

KW - Hepatic venous pressure gradient

UR - http://www.scopus.com/inward/record.url?scp=77950625070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950625070&partnerID=8YFLogxK

U2 - 10.1111/j.1478-3231.2009.02125.x

DO - 10.1111/j.1478-3231.2009.02125.x

M3 - Article

C2 - 19793198

AN - SCOPUS:77950625070

VL - 30

SP - 232

EP - 239

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 2

ER -