Baroreflex impairment by low sodium diet in mild or moderate essential hypertension

Guido Grassi, Bianca Maria Cattaneo, Gino Seravalle, Antonio Lanfranchi, Giambattista Bolla, Giuseppe Mancia

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Low sodium intake is the most widely used nonpharmacological approach to the treatment of hypertension. Although nonpharmacological treatment is by definition regarded as safe, the suggestion has been made that low sodium intake is not totally devoid of inconveniences, and animal data have shown it to be accompanied by an impairment of reflex blood pressure control and homeostasis. However, no data exist on this issue in humans. In mild essential hypertensive patients (age, 34.1±3.3 years [mean±SEM]), we measured beat-to-beat arterial blood pressure (finger photoplethysmographic device), heart rate (electrocardiogram), and efferent postganglionic muscle sympathetic nerve activity (microneurography) at rest and during baroreceptor stimulation and deactivation, induced by stepwise intravenous infusions of phenylephrine and nitroprusside, respectively. Measurements were performed at the end of three dietary periods, ie, after 8 days of regular sodium intake (210 mmol NaCl/d), low sodium intake (20 mmol NaCl/d) with unchanged potassium intake, and again regular sodium intake. Compared with the initial regular sodium diet, low sodium intake reduced urinary sodium excretion, whereas urinary potassium excretion was unchanged. Systolic blood pressure was significantly (P

Original languageEnglish
Pages (from-to)802-807
Number of pages6
JournalHypertension
Volume29
Issue number3
Publication statusPublished - Mar 1997

Fingerprint

Sodium-Restricted Diet
Baroreflex
Sodium
Blood Pressure
Potassium
Pressoreceptors
Nitroprusside
Phenylephrine
Intravenous Infusions
Fingers
Reflex
Essential Hypertension
Arterial Pressure
Electrocardiography
Homeostasis
Heart Rate
Hypertension
Equipment and Supplies
Muscles
Therapeutics

Keywords

  • autonomic nervous system
  • baroreceptors
  • diet, low sodium
  • reflex
  • sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Grassi, G., Cattaneo, B. M., Seravalle, G., Lanfranchi, A., Bolla, G., & Mancia, G. (1997). Baroreflex impairment by low sodium diet in mild or moderate essential hypertension. Hypertension, 29(3), 802-807.

Baroreflex impairment by low sodium diet in mild or moderate essential hypertension. / Grassi, Guido; Cattaneo, Bianca Maria; Seravalle, Gino; Lanfranchi, Antonio; Bolla, Giambattista; Mancia, Giuseppe.

In: Hypertension, Vol. 29, No. 3, 03.1997, p. 802-807.

Research output: Contribution to journalArticle

Grassi, G, Cattaneo, BM, Seravalle, G, Lanfranchi, A, Bolla, G & Mancia, G 1997, 'Baroreflex impairment by low sodium diet in mild or moderate essential hypertension', Hypertension, vol. 29, no. 3, pp. 802-807.
Grassi, Guido ; Cattaneo, Bianca Maria ; Seravalle, Gino ; Lanfranchi, Antonio ; Bolla, Giambattista ; Mancia, Giuseppe. / Baroreflex impairment by low sodium diet in mild or moderate essential hypertension. In: Hypertension. 1997 ; Vol. 29, No. 3. pp. 802-807.
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