Abstract
Baroreceptor mechanisms play a crucial role in healthy humans during a gravitational stimulus to maintain blood pressure and cerebral perfusion by providing proper orthostatic tolerance. In addition, they concur to synchronize central neural discharge activity and hemodynamic spontaneous fluctuations leading to an optimal interaction between the cardiovascular neural regulatory activity and the heart and vessel response. In pathophysiological conditions as encountered before tilt induced neurally-mediated syncope, the gain of baroreflex control of heart rate and muscle sympathetic nerve activity (MSNA) is remarkably impaired, revealing a diminished capability to adapt in response to similar changes of blood pressure compared to healthy subjects. The loss of an organized post-ganglionic sympathetic discharge activity to the vessel leads to orthostatic intolerance in subjects with baroreceptor failure.
| Original language | English |
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| Title of host publication | 1st International Workshop on Innovative Simulation for Health Care, IWISH 2012, Held at the International Multidisciplinary Modeling and Simulation Multiconference, I3M 2012 |
| Publisher | Caltek s.r.l. |
| Pages | 172-174 |
| Number of pages | 3 |
| Publication status | Published - 2012 |
| Event | 1st International Workshop on Innovative Simulation for Health Care, IWISH 2012, Held at the International Multidisciplinary Modeling and Simulation Multiconference, I3M 2012 - Vienna, Austria Duration: Sep 19 2012 → Sep 21 2012 |
Other
| Other | 1st International Workshop on Innovative Simulation for Health Care, IWISH 2012, Held at the International Multidisciplinary Modeling and Simulation Multiconference, I3M 2012 |
|---|---|
| Country | Austria |
| City | Vienna |
| Period | 9/19/12 → 9/21/12 |
Keywords
- Baroreflex sensitivity
- Cardiovascular sympathetic activity
- Gravitational stimulus
- Muscle sympathetic nerve activity
ASJC Scopus subject areas
- Modelling and Simulation
- Health Informatics