Barrett's epithelium after antireflux surgery

Giovanni Zaninotto, Mauro Cassaro, Gianmaria Pennelli, Giorgio Battaglia, Fabio Farinati, Martina Ceolin, Mario Costantini, Alberto Ruol, Emanuela Guirroli, Christian Rizzetto, Giuseppe Portale, Ermanno Ancona, Massimo Rugge

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Barrett's epithelium (BE), defined as endoscopically visible, histologically proved intestinal-type epithelium in the esophagus, is considered the ultimate consequence of long-standing gastro(duodeno)esophageal reflux disease (GERD). Recent reports suggest that effective antireflux therapy may promote the regression of this metaplastic process. This study aimed to establish whether antireflux surgery (laparoscopic fundoplication) can induce any endoscopic and/or histologic changes in BE. Thirty-five consecutive cases of BE (11 short-segment [SBE] and 24 long-segment [LBE]) were considered. All patients underwent extensive biopsy sampling before and after surgery (mean follow-up, 28 months; range, 12-99 mo). In all cases, (a) intestinal metaplasia (IM) extension (H&E), (b) IM phenotype (high-iron diamine [HID]), and (c) Cdx2 immunohistochemical expression were histologically scored in the biopsy material obtained before and after fundoplication. After surgery, a significant decrease in IM extension and a shift from incomplete- to complete-type IM were documented in SBE. No significant changes occurred in the LBE group in terms of IM extension or histochemical phenotype. A drop in the immunohistochemical expression of Cdx2 protein was also only documented in the SBE group. Antireflux surgery significantly modifies the histologic phenotype of SBE, but not of LBE.

Original languageEnglish
Pages (from-to)1253-1261
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume9
Issue number9
DOIs
Publication statusPublished - Dec 1 2005

Fingerprint

Barrett Esophagus
Metaplasia
Fundoplication
Phenotype
Esophageal Diseases
Biopsy
Diamines
Intestinal Mucosa
Gastroesophageal Reflux
Laparoscopy
Esophagus
Iron
Proteins

Keywords

  • Barrett's epithelium
  • Barrett's mucosa
  • Gastro-esophageal reflux
  • Intestinal metaplasia

ASJC Scopus subject areas

  • Surgery

Cite this

Zaninotto, G., Cassaro, M., Pennelli, G., Battaglia, G., Farinati, F., Ceolin, M., ... Rugge, M. (2005). Barrett's epithelium after antireflux surgery. Journal of Gastrointestinal Surgery, 9(9), 1253-1261. https://doi.org/10.1016/j.gassur.2005.09.027

Barrett's epithelium after antireflux surgery. / Zaninotto, Giovanni; Cassaro, Mauro; Pennelli, Gianmaria; Battaglia, Giorgio; Farinati, Fabio; Ceolin, Martina; Costantini, Mario; Ruol, Alberto; Guirroli, Emanuela; Rizzetto, Christian; Portale, Giuseppe; Ancona, Ermanno; Rugge, Massimo.

In: Journal of Gastrointestinal Surgery, Vol. 9, No. 9, 01.12.2005, p. 1253-1261.

Research output: Contribution to journalArticle

Zaninotto, G, Cassaro, M, Pennelli, G, Battaglia, G, Farinati, F, Ceolin, M, Costantini, M, Ruol, A, Guirroli, E, Rizzetto, C, Portale, G, Ancona, E & Rugge, M 2005, 'Barrett's epithelium after antireflux surgery', Journal of Gastrointestinal Surgery, vol. 9, no. 9, pp. 1253-1261. https://doi.org/10.1016/j.gassur.2005.09.027
Zaninotto G, Cassaro M, Pennelli G, Battaglia G, Farinati F, Ceolin M et al. Barrett's epithelium after antireflux surgery. Journal of Gastrointestinal Surgery. 2005 Dec 1;9(9):1253-1261. https://doi.org/10.1016/j.gassur.2005.09.027
Zaninotto, Giovanni ; Cassaro, Mauro ; Pennelli, Gianmaria ; Battaglia, Giorgio ; Farinati, Fabio ; Ceolin, Martina ; Costantini, Mario ; Ruol, Alberto ; Guirroli, Emanuela ; Rizzetto, Christian ; Portale, Giuseppe ; Ancona, Ermanno ; Rugge, Massimo. / Barrett's epithelium after antireflux surgery. In: Journal of Gastrointestinal Surgery. 2005 ; Vol. 9, No. 9. pp. 1253-1261.
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