Barrett's esophagus in patients referred for upper gastrointestinal endoscopy

M. Conio, L. Bonelli, M. Picasso, G. Antonelli, H. Aste, F. Munizzi, S. Sciallero, P. Bruzzi, L. Gocioso, G. Lapertosa, P. Baracchini, E. Fulcheri, P. Ravelli, G. Missale, R. Cestari, A. Picciotto, R. Mele, G. Celle, E. Bovero, R. CheliR. Briglia, O. Podesta, C. Rainisio, G. Marenco, L. Ghezzo, G. Asnaghi, G. F. Ferro, L. Lombardo, M. De La Pierre, R. Ferraris, M. Fracchia, G. B. Babando, R. Sablish, T. Lacchin, G. Benedetti, S. Marchi, F. Costa, G. Maltinti, V. D'Onofrio, G. Iaquinto, G. Macri, G. Salvadori

Research output: Contribution to journalArticlepeer-review


The clinical, endoscopic and histologic features of Barrett's esophagus were evaluated: 20.768 patients underwent upper gastrointestinal endoscopy and 325 of them (1.6%) had multiple biopsies from the distal esophagus because of esophagitis grade 2-4. Metaplastic epithelium was histologically detected in 162 patients (49.8%) and 89 of them (54.9%) showed specialized columnar epithelium. The crude prevalence rate of histologic Barrett's esophagus was 7.8/1000. Barrett's esophagus was 83-fold more frequent among patients complaining of reflux symptoms than among those reporting other symptoms. Daily frequency of reflux symptoms was higher among patients with histologic esophagitis than among those with Barrett's esophagus (p=0.004). Longlasting reflux symptoms were more frequently recorded among patients with Barrett's esophagus than among the others (p=0.004). Barrett's esophagus was histologically detected in 83% of patients with endoscopic Barrett's esophagus and in 36.4% of those with esophagitis. Dysplasia was identified in 9 cases of specialized columnar epithelium. Endoscopy did not prove to be a reliable diagnostic technique to detect Barrett's esophagus and histology represents the gold standard for diagnosis in at risk groups.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalGiornale Italiano di Endoscopia Digestiva
Issue number4
Publication statusPublished - 1996


  • Barrett's esophagus
  • dysplasia
  • esophagitis
  • gastroesophageal reflux symptoms and disease
  • metaplastic epithelium

ASJC Scopus subject areas

  • Gastroenterology


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