Barrett's oesophagus

Long-term follow-up after complete ablation with argon plasma coagulation and the factors that determine its recurrence

R. Ferraris, M. Fracchia, M. Foti, L. Sidoli, S. Taraglio, L. Vigano', C. Giaccone, F. Rebecchi, G. Meineri, C. Senore, A. Pera, C. Bima, F. Bertolino, R. Capussotti, M. Morino, C. Crosta, C. Fiore, V. D'Onofrio, G. Jaquinto, G. Sablich & 2 others T. Lacchin, R. Suriani

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Argon plasma coagulation seems to be a promising technique for ablation of Barrett's oesophagus, yet few long-term efficacy data are available. Aim: To report on a long-term follow-up and the factors that determine the recurrence of intestinal metaplasia in a cohort of patients with non dysplastic, intestinal type Barrett's oesophagus, after complete ablation of the metaplastic mucosa with argon plasma coagulation. Methods: Ninety-six patients underwent endoscopic argon plasma coagulation with adequate acid suppression obtained through a continuous omeprazole therapy (50 patients) or through laparoscopic fundoplication (46 patients). Complete ablation was achieved in 94 patients who underwent follow-up. Endoscopic and histological examinations were performed every 12 months. Results: The median follow-up of the patients was 36 months (range 18-98). A recurrence of intestinal metaplasia was found in 17 patients (18%), with an annual recurrence rate of 6.1%. Neither dysplasia, nor adenocarcinoma were found during the follow-up. Through the use of logistic regression analysis, previous laparoscopic fundoplication was associated with a reduced recurrence rate of intestinal metaplasia (odds ratio 0.30, 95% confidence interval 0.10-0.93). Conclusions: The long-term recurrence of intestinal type Barrett's oesophagus was low after complete ablation with argon plasma coagulation. The control of oesophageal acidity acid exposure with laparoscopic fundoplication seems to reduce the recurrence rate.

Original languageEnglish
Pages (from-to)835-840
Number of pages6
JournalAlimentary Pharmacology and Therapeutics
Volume25
Issue number7
DOIs
Publication statusPublished - Apr 2007

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Argon Plasma Coagulation
Blood Coagulation Factors
Barrett Esophagus
Recurrence
Fundoplication
Metaplasia
Ablation Techniques
Acids
Omeprazole
Mucous Membrane
Adenocarcinoma
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Barrett's oesophagus : Long-term follow-up after complete ablation with argon plasma coagulation and the factors that determine its recurrence. / Ferraris, R.; Fracchia, M.; Foti, M.; Sidoli, L.; Taraglio, S.; Vigano', L.; Giaccone, C.; Rebecchi, F.; Meineri, G.; Senore, C.; Pera, A.; Bima, C.; Bertolino, F.; Capussotti, R.; Morino, M.; Crosta, C.; Fiore, C.; D'Onofrio, V.; Jaquinto, G.; Sablich, G.; Lacchin, T.; Suriani, R.

In: Alimentary Pharmacology and Therapeutics, Vol. 25, No. 7, 04.2007, p. 835-840.

Research output: Contribution to journalArticle

Ferraris, R, Fracchia, M, Foti, M, Sidoli, L, Taraglio, S, Vigano', L, Giaccone, C, Rebecchi, F, Meineri, G, Senore, C, Pera, A, Bima, C, Bertolino, F, Capussotti, R, Morino, M, Crosta, C, Fiore, C, D'Onofrio, V, Jaquinto, G, Sablich, G, Lacchin, T & Suriani, R 2007, 'Barrett's oesophagus: Long-term follow-up after complete ablation with argon plasma coagulation and the factors that determine its recurrence', Alimentary Pharmacology and Therapeutics, vol. 25, no. 7, pp. 835-840. https://doi.org/10.1111/j.1365-2036.2007.03251.x
Ferraris, R. ; Fracchia, M. ; Foti, M. ; Sidoli, L. ; Taraglio, S. ; Vigano', L. ; Giaccone, C. ; Rebecchi, F. ; Meineri, G. ; Senore, C. ; Pera, A. ; Bima, C. ; Bertolino, F. ; Capussotti, R. ; Morino, M. ; Crosta, C. ; Fiore, C. ; D'Onofrio, V. ; Jaquinto, G. ; Sablich, G. ; Lacchin, T. ; Suriani, R. / Barrett's oesophagus : Long-term follow-up after complete ablation with argon plasma coagulation and the factors that determine its recurrence. In: Alimentary Pharmacology and Therapeutics. 2007 ; Vol. 25, No. 7. pp. 835-840.
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abstract = "Background: Argon plasma coagulation seems to be a promising technique for ablation of Barrett's oesophagus, yet few long-term efficacy data are available. Aim: To report on a long-term follow-up and the factors that determine the recurrence of intestinal metaplasia in a cohort of patients with non dysplastic, intestinal type Barrett's oesophagus, after complete ablation of the metaplastic mucosa with argon plasma coagulation. Methods: Ninety-six patients underwent endoscopic argon plasma coagulation with adequate acid suppression obtained through a continuous omeprazole therapy (50 patients) or through laparoscopic fundoplication (46 patients). Complete ablation was achieved in 94 patients who underwent follow-up. Endoscopic and histological examinations were performed every 12 months. Results: The median follow-up of the patients was 36 months (range 18-98). A recurrence of intestinal metaplasia was found in 17 patients (18{\%}), with an annual recurrence rate of 6.1{\%}. Neither dysplasia, nor adenocarcinoma were found during the follow-up. Through the use of logistic regression analysis, previous laparoscopic fundoplication was associated with a reduced recurrence rate of intestinal metaplasia (odds ratio 0.30, 95{\%} confidence interval 0.10-0.93). Conclusions: The long-term recurrence of intestinal type Barrett's oesophagus was low after complete ablation with argon plasma coagulation. The control of oesophageal acidity acid exposure with laparoscopic fundoplication seems to reduce the recurrence rate.",
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T1 - Barrett's oesophagus

T2 - Long-term follow-up after complete ablation with argon plasma coagulation and the factors that determine its recurrence

AU - Ferraris, R.

AU - Fracchia, M.

AU - Foti, M.

AU - Sidoli, L.

AU - Taraglio, S.

AU - Vigano', L.

AU - Giaccone, C.

AU - Rebecchi, F.

AU - Meineri, G.

AU - Senore, C.

AU - Pera, A.

AU - Bima, C.

AU - Bertolino, F.

AU - Capussotti, R.

AU - Morino, M.

AU - Crosta, C.

AU - Fiore, C.

AU - D'Onofrio, V.

AU - Jaquinto, G.

AU - Sablich, G.

AU - Lacchin, T.

AU - Suriani, R.

PY - 2007/4

Y1 - 2007/4

N2 - Background: Argon plasma coagulation seems to be a promising technique for ablation of Barrett's oesophagus, yet few long-term efficacy data are available. Aim: To report on a long-term follow-up and the factors that determine the recurrence of intestinal metaplasia in a cohort of patients with non dysplastic, intestinal type Barrett's oesophagus, after complete ablation of the metaplastic mucosa with argon plasma coagulation. Methods: Ninety-six patients underwent endoscopic argon plasma coagulation with adequate acid suppression obtained through a continuous omeprazole therapy (50 patients) or through laparoscopic fundoplication (46 patients). Complete ablation was achieved in 94 patients who underwent follow-up. Endoscopic and histological examinations were performed every 12 months. Results: The median follow-up of the patients was 36 months (range 18-98). A recurrence of intestinal metaplasia was found in 17 patients (18%), with an annual recurrence rate of 6.1%. Neither dysplasia, nor adenocarcinoma were found during the follow-up. Through the use of logistic regression analysis, previous laparoscopic fundoplication was associated with a reduced recurrence rate of intestinal metaplasia (odds ratio 0.30, 95% confidence interval 0.10-0.93). Conclusions: The long-term recurrence of intestinal type Barrett's oesophagus was low after complete ablation with argon plasma coagulation. The control of oesophageal acidity acid exposure with laparoscopic fundoplication seems to reduce the recurrence rate.

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SN - 0269-2813

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