Barrett’s ulcer and campylobacter-like organisms infection in a child

Costantino D. De Giacomo, Roberto Fiocca, Laura Villani, Laura Bertolotti, Giuseppe Maggiore

Research output: Contribution to journalArticlepeer-review

Abstract

Barrett’s esophagus is a gastrointestinal metaplasia of the esophageal epithelium occurring frequently in adults with long-standing peptic esophagitis. Recent reports of Barrett’s esophagus in children with gastroesophageal reflux (GER) showed that also at the pediatric age intestinal metaplasia of the esophagus may occur in association with peptic esophagitis. Recently a close association between Campylobacter-like organisms (CLOs) and gastritis has been found in the stomach of both adults and children with a variety of peptic diseases, but evidence of such infection in specimens of Barrett’s epithelium has never been described in children. We report here a child with Barrett’s esophagus and GER, treated with H2 blockers, who showed a Barrett’s ulcer in association with CLO infection. The addition of amoxicillin to antireflux treatment was accompanied by healing of the ulcer, suggesting that bacterial infection of Barrett’s epithelium may have an important role in determining its inflammation and possibly ulceration.

Original languageEnglish
Pages (from-to)766-768
Number of pages3
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume7
Issue number5
Publication statusPublished - 1988

Keywords

  • Barrett’s esophagus
  • Barrett’s ulcer
  • campylobacter pylori
  • campylobacter-like organisms
  • Child

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Medicine (miscellaneous)
  • Histology

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