Bartter's syndrome and captopril scintigraphy: A case report

Paolo Colamussi, Stefano Panareo, Corrado Cittanti, Melchiore Giganti, Angelina Filice, Tanja Baresic, Salim El Maoued, Roberto Rizzati, Adriano Piffanelli

Research output: Contribution to journalArticlepeer-review


We report a case of a woman who came to our attention because of hypokalemia, hyperreninemia and hyperaldosteronemia but with normal blood pressure. Under suspicion of a normotensive renal artery stenosis captopril and baseline scintigraphies were performed. Captopril scintigraphy demonstrated a bilateral progressive retention of radiopharmaceutical without significant excretion. The baseline study revealed a complete normalization of the scintigraphyc picture. A Magnetic Resonance Angiography (Angio-MRI) performed to evaluate renal arteries gave completely normal results. On the basis of the clinical picture and imaging findings a diagnosis of Bartter's syndrome was formulated. Renal function in Bartter's syndrome patients is maintained by hyperactivation of the renin angiotensin system. Acute administration of captopril in these patients induces an increase of renal plasma flow whereas it has no effects on glomerular filtration rate thus inducing a decrease of the filtration fraction: post captopril renal scintigraphy of our patient depicted exactly this feature. Although the diagnosis of Bartter's syndrome is based on the clinical picture and biochemical abnormalities, scintigraphic tests could be useful in differentiating Bartter's syndrome from other causes of hypokalemia.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalAnnals of Nuclear Medicine
Issue number2
Publication statusPublished - Apr 2003


  • Bartter's disease
  • Captopril
  • Magnetic resonance angiography
  • Radioisotope renography
  • Technetium-99m MAG3

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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