Basal and bevacizumab-based therapy-induced changes of lactate dehydrogenases and fibrinogen levels and clinical outcome of previously untreated metastatic colorectal cancer patients: A multicentric retrospective analysis

Nicola Silvestris, Mario Scartozzi, Giusi Graziano, Daniele Santini, Vito Lorusso, Evaristo Maiello, Sandro Barni, Saverio Cinieri, Fotios Loupakis, Salvatore Pisconti, Anna Elisabetta Brunetti, Giuseppe Palasciano, Vincenzo Ostilio Palmieri, Michela Del Prete, Emanuela Dell'Aquila, Tiziana Pia Latiano, Fausto Petrelli, Stefania Lutrino, Daniele Rossini, Riccardo GiampieriClaudio Lotesoriere, Stefano Cascinu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To assess the predictive role of lactate dehydrogenases (LDH) and fibrinogen (FBG) serum levels in metastatic colorectal cancer (mCRC) patients receiving a first-line bevacizumab-based therapy.Objectives: The aim of the present analysis was to retrospectively evaluate the role of basal and post-treatment LDH and FBG serum levels in predicting the clinical outcome of 139 mCRC patients receiving first-line chemotherapy in combination with bevacizumab.Results: A statistically significant association between high pre-treatment LDH and FBG levels and progressive disease was observed with respect to low basal LDH and FBG patients. Furthermore, median progression-free survival was 7.3 versus 10.8 months and 7.3 versus 9.4 months for high and low LDH and FBG levels, respectively. Within the high LDH group, we observed a statistically significant reduction of LDH mean value compared with pre-treatment values in patients with objective response rate and stable disease.Conclusions: High LDH and FBG levels correlated with prognosis. A significant correlation between bevacizumab-based chemotherapy-induced reduction in LDH serum levels and response to treatment was observed within the high LDH group. These results, if confirmed in larger prospective studies, could be helpful for early identification of patients responsive to bevacizumab-based chemotherapy or candidate to more aggressive treatments.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalExpert Opinion on Biological Therapy
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Bevacizumab
  • Clinical outcome
  • Colorectal carcinoma
  • Fibrinogen
  • Lactate dehydrogenases

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery
  • Medicine(all)

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