Basal body temperature curves and endocrine pattern of menstrual cycles in Down syndrome

R. M. Cento, L. Ragusa, C. Proto, A. Alberti, C. Romano, G. Boemi, F. Colabucci, A. Lanzone

Research output: Contribution to journalArticlepeer-review


We examined the basal body temperature curves and the endocrine pattern of 20 cycles from women with Down syndrome with regular menstrual cycles. Data were compared with those obtained from an age-matched population of healthy women with regular menses. Growth hormone deficiency was excluded for women with Down syndrome by pharmacological tests. Women with Down syndrome showed a significantly higher incidence of anovulation and luteal defects than controls (p <0.001). Overall, and in ovulatory cycles, estradiol and progesterone plasma levels were greater in controls than in women with Down syndrome. No difference was observed for gonadotrophin and androgen circulating levels between the two groups. It is concluded that in women with Downs syndrome with regular menses, ovulatory events were less frequent and often characterized by luteal defects. This could be ascribed to an impairment of both follicular and luteal functions. However, reproduction is possible in such patients.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalGynecological Endocrinology
Issue number2
Publication statusPublished - 1996


  • Androgens
  • Basal body temperature
  • Down syndrome
  • Estradiol
  • Gonadotropins
  • Menstrual cycle
  • Ovulation
  • Progesterone

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynaecology


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