Basal cell and squamous cell carcinomas. Clinico-histological features

Giorgio Annessi, Giannandrea Baliva

Research output: Contribution to journalArticlepeer-review


Basal cell and squamous cell carcinomas are the most common skin cancers, occurring mainly on sun-damaged skin of old persons. Basal cell carcinoma is a neoplasm of follicular germinative cells which may infiltrate and destroy adjacent tissues, but rarely metastasizes. Five clinico-pathologic types of basal cell carcinomas can be recognized, namely, nodulo-ulcerative, superficial, morpheiform, fibroepithelial, and infundibulo-cystic. Actinic keratosis and Bowen's disease are intrepidermal proliferation of atypical keratinocytes that eventually may progress to become overt squamous cell carcinoma. Lesions arising in sites of chronic injury or scarring bear an higher risk of metastases. Keratoacanthoma is a rapidly evolving tumor of keratinocytes that resolves spontaneously. Keratoacanthoma might represent a self-healing type of squamous cell carcinoma.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalAnnali dell'Istituto Superiore di Sanita
Issue number1
Publication statusPublished - 1996


  • Basal cell carcinoma
  • Keratoacanthoma
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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