Basal ganglia and language: Phonology modulates dopaminergic release

Marco Tettamanti, Andrea Moro, Cristina Messa, Rosa M. Moresco, Giovanna Rizzo, Assunta Carpinelli, Mario Matarrese, Ferruccio Fazio, Daniela Perani

Research output: Contribution to journalArticle

Abstract

Basal ganglia have been implicated in syntactic and phonological processes, but direct evidence has been scarce. Here, we used [11C]raclopride and positron emission tomography to measure modulations of the dopaminergic system induced by phonological or syntactic processing. Two significant effects were found. First, the level of accuracy in phonological processing significantly correlated with tracer binding potential in the left caudate nucleus. Second, the speed in phonological processing significantly correlated with tracer binding potential in the left putamen. Thus, a more accurate and fast phonological processing was associated with a reduced dopamine requirement in the left striatum. These findings show that the striatal dopaminergic system plays an essential role in grammatical processes that form the core of human language.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalNeuroReport
Volume16
Issue number4
DOIs
Publication statusPublished - Mar 15 2005

Keywords

  • Caudate
  • Dopamine
  • Language
  • Phonology
  • Positron emission tomography
  • Putamen
  • Syntax

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Tettamanti, M., Moro, A., Messa, C., Moresco, R. M., Rizzo, G., Carpinelli, A., Matarrese, M., Fazio, F., & Perani, D. (2005). Basal ganglia and language: Phonology modulates dopaminergic release. NeuroReport, 16(4), 397-401. https://doi.org/10.1097/00001756-200503150-00018