Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis

G. Galardi, O. Perani, F. Grassi, S. Bressi, S. Amadio, M. Antoni, G. C. Comi, N. Canal, F. Fazio

Research output: Contribution to journalArticle

Abstract

Introduction - The basal ganglia are thought to be involved in the primary dystonias, largely because of the repeated demonstration of neuropathological changes in these nuclei in the secondary dystonias. A hyperactivity of a network involving basal ganglia has been suggested in experimental animal dystonia. To test this hypothesis in humans, we studied the functional correlates of primary cervical dystonia using [18F]FDG and PET. Material and methods - Regional cerebral glucose metabolism (rCMRglc) was measured in 10 patients with idiopathic torticollis (6 drug-free and 4 drug-naive) and in 15 normal controls, using 2-[18F]-fluoro-2-deoxy-D-glucose ([18F]FDG) and positron emission tomography (PET). Results - A significant hypermetabolism in the basal ganglia, thalamus, premotor-motor cortex and cerebellum in the patients compared with normal controls was found. The patients were correctly assigned to their clinical category by a discriminant function analysis with a total accuracy of 96%. Conclusion - The results support the hypothesis that a dysfunction of a subcortical-cortical motor network may play a role in the pathogenesis of focal dystonia, in agreement with the experimental dystonia models.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalActa Neurologica Scandinavica
Volume94
Issue number3
Publication statusPublished - 1996

Fingerprint

Dystonic Disorders
Torticollis
Basal Ganglia
Dystonia
Fluorodeoxyglucose F18
Motor Cortex
Positron-Emission Tomography
Discriminant Analysis
Thalamus
Pharmaceutical Preparations
Cerebellum
Theoretical Models
Glucose

Keywords

  • Basal ganglia
  • Cerebral glucose metablism
  • Idiopathic dystonia
  • Positron emission tomography
  • Spasmodic torticollis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Galardi, G., Perani, O., Grassi, F., Bressi, S., Amadio, S., Antoni, M., ... Fazio, F. (1996). Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis. Acta Neurologica Scandinavica, 94(3), 172-176.

Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis. / Galardi, G.; Perani, O.; Grassi, F.; Bressi, S.; Amadio, S.; Antoni, M.; Comi, G. C.; Canal, N.; Fazio, F.

In: Acta Neurologica Scandinavica, Vol. 94, No. 3, 1996, p. 172-176.

Research output: Contribution to journalArticle

Galardi, G, Perani, O, Grassi, F, Bressi, S, Amadio, S, Antoni, M, Comi, GC, Canal, N & Fazio, F 1996, 'Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis', Acta Neurologica Scandinavica, vol. 94, no. 3, pp. 172-176.
Galardi G, Perani O, Grassi F, Bressi S, Amadio S, Antoni M et al. Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis. Acta Neurologica Scandinavica. 1996;94(3):172-176.
Galardi, G. ; Perani, O. ; Grassi, F. ; Bressi, S. ; Amadio, S. ; Antoni, M. ; Comi, G. C. ; Canal, N. ; Fazio, F. / Basal ganglia and thalamo-cortical hypermetabolism in patients with spasmodic torticollis. In: Acta Neurologica Scandinavica. 1996 ; Vol. 94, No. 3. pp. 172-176.
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