Basal ganglia local field potentials: Applications in the development of new deep brain stimulation devices for movement disorders

Sara Marceglia, Lorenzo Rossi, Guglielmo Foffani, Anna Maria Bianchi, Sergio Cerutti, Alberto Priori

Research output: Contribution to journalArticle

Abstract

The analysis of neural rhythms measured in local field potentials (LFPs) through deep brain stimulation (DBS) electrodes have provided a new insight into brain mechanisms of information processing. The application of novel methodological approaches for LFP analysis is of key importance to uncover the complexity of such mechanisms, thereby clarifying the relationship between the LFP code and patient's clinical state. Thanks to a new device for recording artifact-free LFPs during high-frequency stimulation, DBS-induced neural rhythms modulations and their nonlinear features can be analyzed and used in the development of a new, adaptive DBS approach: the frequency, strength and site of DBS could be controlled, in a closed-loop system, through LFP-based variables obtained through the application of different methodological approaches.

Original languageEnglish
Pages (from-to)605-614
Number of pages10
JournalExpert Review of Medical Devices
Volume4
Issue number5
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Deep brain stimulation
  • Device
  • Frequency modulation
  • Local field potentials
  • Nonlinear correlation
  • Parkinson's disease

ASJC Scopus subject areas

  • Biophysics
  • Surgery
  • Reviews and References, Medical

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