Basal ganglia network by constrained spherical deconvolution: A possible cortico-pallidal pathway?

Demetrio Milardi, Michele Gaeta, Silvia Marino, Alessandro Arrigo, Gianluigi Vaccarino, Enricomaria Mormina, Giuseppina Rizzo, Carmelo Milazzo, Giovanni Finocchio, Annalisa Baglieri, Giuseppe Anastasi, Angelo Quartarone

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In the recent past, basal ganglia circuitry was simplified as represented by the direct and indirect pathways and by hyperdirect pathways. Based on data from animal studies, we hypothesized a fourth pathway, the cortico-pallidal, pathway, that complements the hyperdirect pathway to the subthalamus. Ten normal brains were analyzed by using the high angular resolution diffusion imaging-constrained spherical deconvolution (CSD)-based technique. The study was performed with a 3T magnetic resonance imaging (MRI) scanner (Achieva, Philips Healthcare, Best, Netherlands); by using a 32-channel SENSE head coil. We showed that CSD is a powerful technique that allows a fine evaluation of both the long and small tracts between cortex and basal ganglia, including direct, indirect, and hyperdirect pathways. In addition, a pathway directly connecting the cortex to the globus pallidus was seen. Our results confirm that the CSD tractography is a valuable technique allowing a reliable reconstruction of small- and long-fiber pathways in brain regions with multiple fiber orientations, such as basal ganglia. This could open a future scenario in which CSD could be used to focally target with deep brain stimulation (DBS) the small bundles within the basal ganglia loops.

Original languageEnglish
Pages (from-to)342-349
Number of pages8
JournalMovement Disorders
Volume30
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Basal Ganglia
Subthalamus
Globus Pallidus
Deep Brain Stimulation
Brain
Netherlands
Head
Magnetic Resonance Imaging
Delivery of Health Care

Keywords

  • Basal ganglia
  • Brain
  • CSD
  • Subthalamic nucleus
  • Tractography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Basal ganglia network by constrained spherical deconvolution : A possible cortico-pallidal pathway? / Milardi, Demetrio; Gaeta, Michele; Marino, Silvia; Arrigo, Alessandro; Vaccarino, Gianluigi; Mormina, Enricomaria; Rizzo, Giuseppina; Milazzo, Carmelo; Finocchio, Giovanni; Baglieri, Annalisa; Anastasi, Giuseppe; Quartarone, Angelo.

In: Movement Disorders, Vol. 30, No. 3, 01.03.2015, p. 342-349.

Research output: Contribution to journalArticle

Milardi, D, Gaeta, M, Marino, S, Arrigo, A, Vaccarino, G, Mormina, E, Rizzo, G, Milazzo, C, Finocchio, G, Baglieri, A, Anastasi, G & Quartarone, A 2015, 'Basal ganglia network by constrained spherical deconvolution: A possible cortico-pallidal pathway?', Movement Disorders, vol. 30, no. 3, pp. 342-349. https://doi.org/10.1002/mds.25995
Milardi, Demetrio ; Gaeta, Michele ; Marino, Silvia ; Arrigo, Alessandro ; Vaccarino, Gianluigi ; Mormina, Enricomaria ; Rizzo, Giuseppina ; Milazzo, Carmelo ; Finocchio, Giovanni ; Baglieri, Annalisa ; Anastasi, Giuseppe ; Quartarone, Angelo. / Basal ganglia network by constrained spherical deconvolution : A possible cortico-pallidal pathway?. In: Movement Disorders. 2015 ; Vol. 30, No. 3. pp. 342-349.
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