Abstract
Basal plasma levels of immunoreactive calcitonin (iCT), forearm bone mineral cotent (BMC) as measured by 125I photon absorptiometry and 24-hour urinary hydroxyproline/creatinine ratio (OHPr/Cr) were determined in 32 healthy women (13 pre-menopausal, aged 40 to 54 years, and 19 post-menopausal, aged 41 to 54 years). The basal plasma levels of iCT were significantly higher in the pre-menopausal group (mean value 96 vs 54 pg/ml, P <0.025). The BMC value of the radius was also significantly greater in the same group (mean ± SEM 656 ± 13 vs. 620 ± 9 m/cm2, P <0.05), while the urinary OHPr/Cr ratio was higher in the post-menopausal group (29.9 ± 1.5 vs. 38.7 ± 2.7 mg/g, P <0.02). These results suggest that basal plasma levels of iCT decrease after the menopause and support the hypothesis that a deficiency of CT could be involved in the pathogenesis of post-menopausal bone loss. Similar results were obtained in 25 uremic women on maintenance hemodialysis (9 pre-menopausal and 16 post-menopausal) aged 30 to 65 yrs.: both basal iCT levels and BMC values were significantly higher in the pre-menopausal group.
| Original language | English |
|---|---|
| Pages (from-to) | 263-265 |
| Number of pages | 3 |
| Journal | Biomedicine and Pharmacotherapy |
| Volume | 38 |
| Issue number | 5 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Basal plasma levels of calcitonin and bone mineral mass in normal and uremic women. Effect of menopause. / Corghi, E.; Ortolani, S.; Bianchi, M. L.; Favini, P.; Vigo, P.; Polli, E. E.
In: Biomedicine and Pharmacotherapy, Vol. 38, No. 5, 1984, p. 263-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Basal plasma levels of calcitonin and bone mineral mass in normal and uremic women. Effect of menopause
AU - Corghi, E.
AU - Ortolani, S.
AU - Bianchi, M. L.
AU - Favini, P.
AU - Vigo, P.
AU - Polli, E. E.
PY - 1984
Y1 - 1984
N2 - Basal plasma levels of immunoreactive calcitonin (iCT), forearm bone mineral cotent (BMC) as measured by 125I photon absorptiometry and 24-hour urinary hydroxyproline/creatinine ratio (OHPr/Cr) were determined in 32 healthy women (13 pre-menopausal, aged 40 to 54 years, and 19 post-menopausal, aged 41 to 54 years). The basal plasma levels of iCT were significantly higher in the pre-menopausal group (mean value 96 vs 54 pg/ml, P <0.025). The BMC value of the radius was also significantly greater in the same group (mean ± SEM 656 ± 13 vs. 620 ± 9 m/cm2, P <0.05), while the urinary OHPr/Cr ratio was higher in the post-menopausal group (29.9 ± 1.5 vs. 38.7 ± 2.7 mg/g, P <0.02). These results suggest that basal plasma levels of iCT decrease after the menopause and support the hypothesis that a deficiency of CT could be involved in the pathogenesis of post-menopausal bone loss. Similar results were obtained in 25 uremic women on maintenance hemodialysis (9 pre-menopausal and 16 post-menopausal) aged 30 to 65 yrs.: both basal iCT levels and BMC values were significantly higher in the pre-menopausal group.
AB - Basal plasma levels of immunoreactive calcitonin (iCT), forearm bone mineral cotent (BMC) as measured by 125I photon absorptiometry and 24-hour urinary hydroxyproline/creatinine ratio (OHPr/Cr) were determined in 32 healthy women (13 pre-menopausal, aged 40 to 54 years, and 19 post-menopausal, aged 41 to 54 years). The basal plasma levels of iCT were significantly higher in the pre-menopausal group (mean value 96 vs 54 pg/ml, P <0.025). The BMC value of the radius was also significantly greater in the same group (mean ± SEM 656 ± 13 vs. 620 ± 9 m/cm2, P <0.05), while the urinary OHPr/Cr ratio was higher in the post-menopausal group (29.9 ± 1.5 vs. 38.7 ± 2.7 mg/g, P <0.02). These results suggest that basal plasma levels of iCT decrease after the menopause and support the hypothesis that a deficiency of CT could be involved in the pathogenesis of post-menopausal bone loss. Similar results were obtained in 25 uremic women on maintenance hemodialysis (9 pre-menopausal and 16 post-menopausal) aged 30 to 65 yrs.: both basal iCT levels and BMC values were significantly higher in the pre-menopausal group.
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M3 - Article
C2 - 6525424
AN - SCOPUS:0021735949
VL - 38
SP - 263
EP - 265
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
IS - 5
ER -