Basaloid squamous cell carcinoma: a rare tumor at the esophagogastric junction and an unexpected durable complete response to FOLFOX-4.

Chiara A. Cella, Chiara Carlomagno, Florian Lordick, Roberto Moretto, Alfonso De Stefano, Lucia Raimondo, Maria D'Armiento, Luigi Camera, Elia Guadagno, Laura Attademo, Salvatore Feliciano, Elide Matano

Research output: Contribution to journalArticlepeer-review

Abstract

Basaloid squamous cell carcinoma (BSCC) is a high-grade variant of squamous cell carcinoma usually localized in the aerodigestive tract, with a poor prognosis. Surgical resection is generally recommended, even if no standard treatment has been established yet. Here, we report the case history of a patient diagnosed with BSCC at the esophagogastric junction who was successfully treated with chemotherapy alone, leading to a durable complete response. The presented case illustrates the diagnostic challenges associated with BSCC of the esophagus and reports an unexpected chemosensitivity of this histotype to the combination of a platinum salt plus 5-fluorouracil, which could represent an optimal treatment strategy in unfit patients.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalOncology Research and Treatment
Volume37
Issue number1-2
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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