Il carcinoma squamoso basaloide della laringe: una nuova entità morfologica. Presentazione di un caso.

Translated title of the contribution: Basaloid-squamous cell carcinoma of the larynx: a new morphologic entity. Case report

F. Ferrario, G. Spriano, A. Macchi, R. Piantanida, L. Della Vecchia

Research output: Contribution to journalArticlepeer-review


Basaloid-Squamous Cell Carcinoma (BSCC) is considered a biologically aggressive variation of squamous cell carcinoma (SCC). Wain et al. first reported BSCC as an independent neoplasm in 1986. In the past, it was most likely misinterpreted as atypical SCC. To date approximately one hundred cases have been reported in the literature. The pathognomonic characteristic of BSCC is an intimate association between basaloid and squamous patterns: for this reason a small biopsy specimen may be insufficient for correct diagnosis. In such cases, knowledge of the biological behavior of these tumors (i.e. local aggressiveness and tendency to spread both regionally and at a distance) may prove useful. Prognosis and survival rates are certainly worse than in SCC. Within the upper aero-digestive tract, BSCC is most likely to arise in the supraglottic larynx, the pyriform sinus and the base of the tongue. Treatment should include surgery of the primary tumor and of the neck lymph nodes, followed by radiotherapy. The authors present a new case report indicating the typical feature of this tumor (aggressiveness, synchronous basaloid and squamous histology, supraglottic involvement.

Translated title of the contributionBasaloid-squamous cell carcinoma of the larynx: a new morphologic entity. Case report
Original languageItalian
Pages (from-to)338-341
Number of pages4
JournalActa Otorhinolaryngologica Italica
Issue number5
Publication statusPublished - Oct 1998

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Basaloid-squamous cell carcinoma of the larynx: a new morphologic entity. Case report'. Together they form a unique fingerprint.

Cite this