Baseline and mitomycin C(MMC)-induced sister-chromatid exchanges in XX and XY cells of Callithrix jacchus chimeric twins

M. P. Bigatti, L. Lambert, S. Crovella, G. Ardito

Research output: Contribution to journalArticlepeer-review

Abstract

Lymphocytes from chimetric individuals of the species Callithrix jacchus (Primates) were examined to evaluate differences in the frequency of sister chromatid exchanges (SCE) between XX and XY cells. The aim was to discover whether SCE differ according to genetic sex and whether XX and XY cells show a different sensitivity to SCE inducing agents. This experimental model has enabled us to eliminate the possible differences caused by environmental factors. The results obtained do not reveal significant differences between male and female cells, in either the baseline SCE frequency or that induced by mitomycin C at concentrations of 0.01 and 0.03 μg/ml. No signficant differences were observed in the distribution of high SCE frequency cells (HFC), even if it is possible to observe a higher level of exchanges in XX cells in each trial. With regard to the phenotypic sex, there appears to be a trend towards slightly higher SCE rates in females, even if results are not statistically significant.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalMutation Research Letters
Volume347
Issue number3-4
DOIs
Publication statusPublished - 1995

Keywords

  • Callithrix jacchus
  • Chimera-Lymphocytes culture
  • Mitomycin C
  • Sister-chromatid exchange

ASJC Scopus subject areas

  • Genetics
  • Toxicology

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