Baseline characteristics of systemic lupus erythematosus patients included in the Lupus Italian Registry of the Italian Society for Rheumatology

Gian Domenico Sebastiani, Francesca Romana Spinelli, Elena Bartoloni, Alessandra Bortoluzzi, Enrica Bozzolo, Claudia Canofari, Valentina Canti, Paola Conigliaro, Maria Chiara Ditto, Giacomo Emmi, Franco Franceschini, Micol Frassi, Luca Iaccarino, Annamaria Iuliano, Angelo Manfredi, Viviana Pacucci, Simone Parisi, Giulia Pazzola, Roberto Perricone, Immacolata PreveteGiuseppe Alvise Ramirez, Salvatore Scarpato, Chiara Scirocco, Ettore Silvagni, Margherita Zen, Anna Zanetti, Greta Carrara, Carlo Alberto Scirè, Fabrizio Conti, Andrea Doria

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To report baseline data of SLE patients enrolled in the Lupus Italian Registry (LIRE). Methods: Patients affected by SLE aged ≥ 16 years were consecutively recruited in a multicenter prospective study comparing two cohorts: patients starting biologic immunosuppressants (BC) and patients starting non-biologic immunosuppresants (NBC). Results: 308 patients were enrolled, 179 in NBC and 129 in BC. Mean age at disease onset and at diagnosis was significantly higher in NBC (p = 0.023, p = 0.045, respectively). Disease duration was longer in BC (p = 0.022). Patients in BC presented arthritis more frequently (p = 0.024), those in NBC nephropathy (p = 0.03). Quality of life was worse in BC (p = 0.031). Anti-dsDNA, low C3, were significantly more frequent in BC (p < 0.001, p = 0.009, respectively). Mycophenolate, methotrexate and azathioprine were the drugs more frequently prescribed in NBC, Belimumab and Rituximab in BC. Conclusion: The predominant organ involvement was different in the two cohorts: kidney involvement predominated in NBC, joint involvement in BC. Despite the younger age at disease onset, patients of the BC had a longer disease duration and more frequently had taken a cumulative prednisone dosage greater than 10 g. Even the pattern of clinical manifestations inducing to prescribe biological rather than conventional immunosuppressants was quite different. Keywords: Autoantibody(ies), autoimmune disease, belimumab, cohort studies, glucocorticoids, immunosuppressants, rituximab, systemic lupus erythematosus.

Original languageEnglish
Pages (from-to)1233-1243
Number of pages11
JournalLupus
Volume30
Issue number8
DOIs
Publication statusPublished - Jul 2021

ASJC Scopus subject areas

  • Rheumatology

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