Baseline charateristics of the population enrolled in the Italian Observational Study on Severe Osteoporosis (ISSO)

S. Adami, D. Maugeri, V. Toscano, G. Topa, M. Caminiti, A. Brancati, M. Massarotti, G. Osella, N. Malavolta, G. Iolascon, C. Cagnoni, V. Camozzi, C. Corradini, A. Nardi, S. Migliaccio, F. M. Ulivieri, G. Resmini, D. Valle, L. Tauchmanova, Sandra Silvestri

Research output: Contribution to journalArticle

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Abstract

Objective: Baseline characteristics of the population enrolled in the ISSO study, designed to evaluate the incidence of vertebral and non-vertebral fractures in Italian patients with severe osteoporosis treated according to clinical practice over 24 months observation. Methods: Prospective observational study in 783 post-menopausal women and men entering 18-month treatment with teriparatide in a community setting at 57 centres in Italy. Characterisation included demographics, fracture risk factors, bone mineral density, fracture status, Health-Related Quality of Life (HRQoL) measured by the European Quality of Life Questionnaire, EQ-5D, and back pain assessed by VAS. Results: Most patients were elderly women (90.5%), mean age±SD was 72.9±8.8 years. Nearly all (91.3%) had experienced ≥1 vertebral fracture (mean±SD, 3.6±2.2 per patient), 37.5% had ≥1 non-vertebral fracture (mean±SD, 1.4±0.7 per patient). Nearly all patients were suffering from back pain (94.9%), which had significantly restricted their daily activities (51.7%) and had likely or very likely been caused by vertebral fractures (29.2% and 55.8%, respectively). Mean EuroQoL EQ-5D index value was 0.58±0.25 and VAS score 49.2±23.6. Non-vertebral fractures, back pain and multiple vertebral fractures were associated with lower HRQoL (EuroQoLSD Index both p

Original languageEnglish
Pages (from-to)477-484
Number of pages8
JournalClinical and Experimental Rheumatology
Volume29
Issue number3
Publication statusPublished - 2011

Fingerprint

Osteoporosis
Observational Studies
Back Pain
Population
Quality of Life
Teriparatide
Population Characteristics
Bone Density
Italy
Observation
Demography
Prospective Studies
Incidence
Therapeutics

Keywords

  • Back pain
  • Fractures
  • Observational study
  • Osteoporosis
  • Quality of life
  • Risk factors
  • Treatment

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Adami, S., Maugeri, D., Toscano, V., Topa, G., Caminiti, M., Brancati, A., ... Silvestri, S. (2011). Baseline charateristics of the population enrolled in the Italian Observational Study on Severe Osteoporosis (ISSO). Clinical and Experimental Rheumatology, 29(3), 477-484.

Baseline charateristics of the population enrolled in the Italian Observational Study on Severe Osteoporosis (ISSO). / Adami, S.; Maugeri, D.; Toscano, V.; Topa, G.; Caminiti, M.; Brancati, A.; Massarotti, M.; Osella, G.; Malavolta, N.; Iolascon, G.; Cagnoni, C.; Camozzi, V.; Corradini, C.; Nardi, A.; Migliaccio, S.; Ulivieri, F. M.; Resmini, G.; Valle, D.; Tauchmanova, L.; Silvestri, Sandra.

In: Clinical and Experimental Rheumatology, Vol. 29, No. 3, 2011, p. 477-484.

Research output: Contribution to journalArticle

Adami, S, Maugeri, D, Toscano, V, Topa, G, Caminiti, M, Brancati, A, Massarotti, M, Osella, G, Malavolta, N, Iolascon, G, Cagnoni, C, Camozzi, V, Corradini, C, Nardi, A, Migliaccio, S, Ulivieri, FM, Resmini, G, Valle, D, Tauchmanova, L & Silvestri, S 2011, 'Baseline charateristics of the population enrolled in the Italian Observational Study on Severe Osteoporosis (ISSO)', Clinical and Experimental Rheumatology, vol. 29, no. 3, pp. 477-484.
Adami, S. ; Maugeri, D. ; Toscano, V. ; Topa, G. ; Caminiti, M. ; Brancati, A. ; Massarotti, M. ; Osella, G. ; Malavolta, N. ; Iolascon, G. ; Cagnoni, C. ; Camozzi, V. ; Corradini, C. ; Nardi, A. ; Migliaccio, S. ; Ulivieri, F. M. ; Resmini, G. ; Valle, D. ; Tauchmanova, L. ; Silvestri, Sandra. / Baseline charateristics of the population enrolled in the Italian Observational Study on Severe Osteoporosis (ISSO). In: Clinical and Experimental Rheumatology. 2011 ; Vol. 29, No. 3. pp. 477-484.
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AU - Maugeri, D.

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AU - Topa, G.

AU - Caminiti, M.

AU - Brancati, A.

AU - Massarotti, M.

AU - Osella, G.

AU - Malavolta, N.

AU - Iolascon, G.

AU - Cagnoni, C.

AU - Camozzi, V.

AU - Corradini, C.

AU - Nardi, A.

AU - Migliaccio, S.

AU - Ulivieri, F. M.

AU - Resmini, G.

AU - Valle, D.

AU - Tauchmanova, L.

AU - Silvestri, Sandra

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