Baseline left ventricular volume and shape as determinants of reverse remodeling induced by surgical ventricular reconstruction

Marisa Di Donato, Serenella Castelvecchio, Daniel Burkhoff, Alessandro Frigiola, Abdallah Raweh, Lorenzo Menicanti

Research output: Contribution to journalArticlepeer-review


Background: Early postoperative data show that surgical ventricular reconstruction (SVR) induces reverse remodelling (RR) in dilated ischemic cardiomyopathy. The stability of these results at follow-up is debated. This retrospective study determined whether RR was stable at follow-up and the role, if any, of preoperative left ventricle volume and shape on SVR-induced changes. Methods: The study group comprised 220 patients (age, 64 ± 9 years) with an echocardiography study at baseline, discharge, and at follow-up. RR was defined as a reduction of left ventricular end-systolic volume index (ESVI) at follow-up exceeding 15% vs baseline. Results: Reverse remodelling occurred in 162 patients (74%); the ESVI at follow-up in the remaining 58 (26%) was equal to or greater than at baseline (no-RR). At baseline, the no-RR patients had lower volumes and higher ejection fraction; at the 1-week post-SVR evaluation, all patients reached significant ESV reduction, but at follow-up, the no-RR patients had dilated and showed significantly higher volumes and lower ejection fraction vs patients with RR. New York Heart Association class improved in both groups (2.6 ± 0.6 to 1.6 ± 0.5 and 2.5 ± 0.8 to 1.8 ± 0.7, respectively, p = 0.0001). Baseline ESVI less than 73 mL/m 2, apical axis less than 4.35 cm, and conicity index less than 0.759 were predictors of no-RR. Conclusions: A relatively small ESVI and a more physiologic apical shape (conical) are predictors of no-RR after SVR. Despite lack of RR, the ESV at follow-up is not severely enlarged, which explains the good survival rate in these patients.

Original languageEnglish
Pages (from-to)1565-1572
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number5
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine


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