Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxaliplatin-fluoropyrimidine doublet

Pasquale Comella, Rossana Casaretti, Raffaella Manzo, Claudia Sandomenico, Marina Licenziato, Antonio Avallone, Luca Franco, Bruno Massidda, Gianfranco Filippelli, Carlo Putzu, Donato Natale, Giuseppe Barberis, Luigi Maiorino, Sergio Palmeri, Michele Cannone, Giovanni Condemi, Silvana Leo, Salvatore Tafuto, Ettore Greco, Mario RoselliValerio Milia, Antonio Gambardella, Sergio Mancarella, Giancarlo Di Pinto, Lucio De Luca, Giacomo Vessia

Research output: Contribution to journalArticle

Abstract

Background. No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. Methods. We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = 99), or inferior to the lowest quartile (n = 100). The relationship between these three groups and the ECOG PS was then analysed. Results. At multivariate analysis, OS was negatively affected by the number of metastatic sites, the serum alkaline phosphatase, and the ECOG PS, while it was positively affected by the previous surgical resection of the primary tumour. Adding the baseline PF score, the number of disease sites (p <0.0001), the serum alkaline phosphatase (p = 0.0057), and the PF (p = 0.0007) retained an independent significance, while the ECOG PS and the previous surgery were no longer significant. PF did not significantly affect PFS or RR. A good but not totally overlapping correlation was found between PF grouping and ECOG PS score. Conclusions. Baseline self-reported PF independently predicted the OS of patients. Assessment of QoL should be incorporated in randomised trials evaluating the management of patients with MCRC.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalActa Oncologica
Volume49
Issue number1
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

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    Comella, P., Casaretti, R., Manzo, R., Sandomenico, C., Licenziato, M., Avallone, A., Franco, L., Massidda, B., Filippelli, G., Putzu, C., Natale, D., Barberis, G., Maiorino, L., Palmeri, S., Cannone, M., Condemi, G., Leo, S., Tafuto, S., Greco, E., ... Vessia, G. (2010). Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxaliplatin-fluoropyrimidine doublet. Acta Oncologica, 49(1), 50-56. https://doi.org/10.3109/02841860903369540