Basic fibroblast growth factor in human pheochromocytoma: A biochemical and immunohistochemical study

M. Statuto, M. G. Ennas, G. Zamboni, F. Bonetti, M. Pea, F. Bernardello, A. Pozzi, M. Rusnati, A. Gualandris, M. Presta

Research output: Contribution to journalArticle

Abstract

Biopsies of human normal adrenal medulla, adrenal pheochromocytoma, and chemodectoma were studied for the presence of basic fibroblast growth factor (bFGF). An immunoreactive Mr 18,000 bFGF-like molecule was detected both in normal and neoplastic tissues. This molecule was identified as bFGF on the basis of its molecular weight, its affinity for heparin, and its capacity to induce plasminogen activator production in cultured endothelial GM 7373 cells. The levels of immunoreactive and biologically active bFGF appeared to be significantly higher in the extracts of adrenal pheochromocytoma and chemodectoma than in the extracts of normal adrenal medulla. bFGF immunostaining was detectable in the nuclei of chief (Type-I) cells and of endothelial cells both in normal adrenal medulla and in pheochromocytoma. Cytoplasmic bFGF positivity of endothelial cells was also observed in pheochromocytoma but not in normal tissue. The data are in keeping with the hypothesis that bFGF may exert autocrine and paracrine functions in the growth and neovascularization of human pheochromocytoma.

Original languageEnglish
Pages (from-to)5-10
Number of pages6
JournalInternational Journal of Cancer
Volume53
Issue number1
DOIs
Publication statusPublished - 1993

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Pheochromocytoma
Fibroblast Growth Factor 2
Adrenal Medulla
Extra-Adrenal Paraganglioma
Endothelial Cells
Plasminogen Activators
Heparin
Molecular Weight
Biopsy
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Statuto, M., Ennas, M. G., Zamboni, G., Bonetti, F., Pea, M., Bernardello, F., ... Presta, M. (1993). Basic fibroblast growth factor in human pheochromocytoma: A biochemical and immunohistochemical study. International Journal of Cancer, 53(1), 5-10. https://doi.org/10.1002/ijc.2910530103

Basic fibroblast growth factor in human pheochromocytoma : A biochemical and immunohistochemical study. / Statuto, M.; Ennas, M. G.; Zamboni, G.; Bonetti, F.; Pea, M.; Bernardello, F.; Pozzi, A.; Rusnati, M.; Gualandris, A.; Presta, M.

In: International Journal of Cancer, Vol. 53, No. 1, 1993, p. 5-10.

Research output: Contribution to journalArticle

Statuto, M, Ennas, MG, Zamboni, G, Bonetti, F, Pea, M, Bernardello, F, Pozzi, A, Rusnati, M, Gualandris, A & Presta, M 1993, 'Basic fibroblast growth factor in human pheochromocytoma: A biochemical and immunohistochemical study', International Journal of Cancer, vol. 53, no. 1, pp. 5-10. https://doi.org/10.1002/ijc.2910530103
Statuto, M. ; Ennas, M. G. ; Zamboni, G. ; Bonetti, F. ; Pea, M. ; Bernardello, F. ; Pozzi, A. ; Rusnati, M. ; Gualandris, A. ; Presta, M. / Basic fibroblast growth factor in human pheochromocytoma : A biochemical and immunohistochemical study. In: International Journal of Cancer. 1993 ; Vol. 53, No. 1. pp. 5-10.
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