Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor

Paul Okunieff, Edward H. Abraham, Marjaneh Moini, Matthew L. Snyder, Torsten R. Gloe, Maurizio C. Capogrossi, Ivan Ding

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We examined the potential of bFGF to function as a radioprotector of bone marrow (BM). Total intravenous doses of bFGF ranged from 1 to 24 μg/mouse, in 2 divided doses. Whole body radiation (WBI) was given in a single fraction to C3H mice. Histologic observations were performed on femur BM at various times after bFGF (or placebo) treatment. Thigh radiation in thigh-tumor bearing mice was delivered in a single fraction. bFGF increased the LD50/30 of mice in a dose dependent fashion, with an apparent maximum protection obtained with ≥6 μg given half 24 h and half 4 h before irradiation. BM histology shows prominent recovery of megakaryocytes and all cell lineages along with less loss in cellularity compared to control irradiated animals. No radioprotection of RIF1 tumors after bFGF was detected. These results indicate that bFGF may be a selective radioprotector of normal tissue.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalActa Oncologica
Volume34
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Fibroblast Growth Factor 2
Bone Marrow
Thigh
Neoplasms
Megakaryocytes
Inbred C3H Mouse
Whole-Body Irradiation
Lethal Dose 50
Cell Lineage
Femur
Histology
Placebos
Radiation
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Okunieff, P., Abraham, E. H., Moini, M., Snyder, M. L., Gloe, T. R., Capogrossi, M. C., & Ding, I. (1995). Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor. Acta Oncologica, 34(3), 435-438. https://doi.org/10.3109/02841869509094004

Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor. / Okunieff, Paul; Abraham, Edward H.; Moini, Marjaneh; Snyder, Matthew L.; Gloe, Torsten R.; Capogrossi, Maurizio C.; Ding, Ivan.

In: Acta Oncologica, Vol. 34, No. 3, 1995, p. 435-438.

Research output: Contribution to journalArticle

Okunieff, P, Abraham, EH, Moini, M, Snyder, ML, Gloe, TR, Capogrossi, MC & Ding, I 1995, 'Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor', Acta Oncologica, vol. 34, no. 3, pp. 435-438. https://doi.org/10.3109/02841869509094004
Okunieff P, Abraham EH, Moini M, Snyder ML, Gloe TR, Capogrossi MC et al. Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor. Acta Oncologica. 1995;34(3):435-438. https://doi.org/10.3109/02841869509094004
Okunieff, Paul ; Abraham, Edward H. ; Moini, Marjaneh ; Snyder, Matthew L. ; Gloe, Torsten R. ; Capogrossi, Maurizio C. ; Ding, Ivan. / Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor. In: Acta Oncologica. 1995 ; Vol. 34, No. 3. pp. 435-438.
@article{6c6a5647ef394bf4a121fe3397cab4cf,
title = "Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor",
abstract = "We examined the potential of bFGF to function as a radioprotector of bone marrow (BM). Total intravenous doses of bFGF ranged from 1 to 24 μg/mouse, in 2 divided doses. Whole body radiation (WBI) was given in a single fraction to C3H mice. Histologic observations were performed on femur BM at various times after bFGF (or placebo) treatment. Thigh radiation in thigh-tumor bearing mice was delivered in a single fraction. bFGF increased the LD50/30 of mice in a dose dependent fashion, with an apparent maximum protection obtained with ≥6 μg given half 24 h and half 4 h before irradiation. BM histology shows prominent recovery of megakaryocytes and all cell lineages along with less loss in cellularity compared to control irradiated animals. No radioprotection of RIF1 tumors after bFGF was detected. These results indicate that bFGF may be a selective radioprotector of normal tissue.",
author = "Paul Okunieff and Abraham, {Edward H.} and Marjaneh Moini and Snyder, {Matthew L.} and Gloe, {Torsten R.} and Capogrossi, {Maurizio C.} and Ivan Ding",
year = "1995",
doi = "10.3109/02841869509094004",
language = "English",
volume = "34",
pages = "435--438",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor

AU - Okunieff, Paul

AU - Abraham, Edward H.

AU - Moini, Marjaneh

AU - Snyder, Matthew L.

AU - Gloe, Torsten R.

AU - Capogrossi, Maurizio C.

AU - Ding, Ivan

PY - 1995

Y1 - 1995

N2 - We examined the potential of bFGF to function as a radioprotector of bone marrow (BM). Total intravenous doses of bFGF ranged from 1 to 24 μg/mouse, in 2 divided doses. Whole body radiation (WBI) was given in a single fraction to C3H mice. Histologic observations were performed on femur BM at various times after bFGF (or placebo) treatment. Thigh radiation in thigh-tumor bearing mice was delivered in a single fraction. bFGF increased the LD50/30 of mice in a dose dependent fashion, with an apparent maximum protection obtained with ≥6 μg given half 24 h and half 4 h before irradiation. BM histology shows prominent recovery of megakaryocytes and all cell lineages along with less loss in cellularity compared to control irradiated animals. No radioprotection of RIF1 tumors after bFGF was detected. These results indicate that bFGF may be a selective radioprotector of normal tissue.

AB - We examined the potential of bFGF to function as a radioprotector of bone marrow (BM). Total intravenous doses of bFGF ranged from 1 to 24 μg/mouse, in 2 divided doses. Whole body radiation (WBI) was given in a single fraction to C3H mice. Histologic observations were performed on femur BM at various times after bFGF (or placebo) treatment. Thigh radiation in thigh-tumor bearing mice was delivered in a single fraction. bFGF increased the LD50/30 of mice in a dose dependent fashion, with an apparent maximum protection obtained with ≥6 μg given half 24 h and half 4 h before irradiation. BM histology shows prominent recovery of megakaryocytes and all cell lineages along with less loss in cellularity compared to control irradiated animals. No radioprotection of RIF1 tumors after bFGF was detected. These results indicate that bFGF may be a selective radioprotector of normal tissue.

UR - http://www.scopus.com/inward/record.url?scp=0029039798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029039798&partnerID=8YFLogxK

U2 - 10.3109/02841869509094004

DO - 10.3109/02841869509094004

M3 - Article

VL - 34

SP - 435

EP - 438

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 3

ER -