Basic Mechanisms of Synthesis and Hydrolysis of Major Endocannabinoids

Natalia Battista, Mauro Maccarrone

Research output: Chapter in Book/Report/Conference proceedingChapter


Twenty-five years after the discovery of the first cannabinoid receptor, several efforts have been made to identify the biochemical routes potentially used by cells to produce its endogenous ligands anandamide and 2-arachidonoylglycerol. These endocannabinoids (eCBs) are key molecules engaged in multiple biological processes that, together with their molecular targets, biosynthetic and catabolic enzymes, form the so-called "endocannabinoid system." Despite the development of selective pharmacological and genetic tools to target eCB metabolic enzymes, there are still some missing pieces that prevent a full understanding of eCB biosynthesis and hydrolysis. In this chapter, we will review the latest advances on the metabolic pathways that account for production and degradation of eCBs.

Original languageEnglish
Title of host publicationThe Endocannabinoid System
Subtitle of host publicationGenetics, Biochemistry, Brain Disorders, and Therapy
PublisherElsevier Inc.
Number of pages23
ISBN (Electronic)9780128096673
ISBN (Print)9780128096666
Publication statusPublished - May 16 2017


  • 2-Arachidonoylglycerol
  • Anandamide
  • Biosynthesis
  • Catabolism
  • Endocannabinoids metabolic routes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


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