Basic principles of biobanking: from biological samples to precision medicine for patients.

Laura Annaratone, Giuseppe De Palma, Giuseppina Bonizzi, Anna Sapino, Gerardo Botti, Enrico Berrino, Chiara Mannelli, Pamela Arcella, Simona Di Martino, Agostino Steffan, Maria Grazia Daidone, Vincenzo Canzonieri, Barbara Parodi, Angelo Virgilio Paradiso, Massimo Barberis, Caterina Marchiò, Alleanza Contro il Cancro (ACC) Pathology and Biobanking Working Group

Research output: Contribution to journalArticlepeer-review


The term "biobanking" is often misapplied to any collection of human biological materials (biospecimens) regardless of requirements related to ethical and legal issues or the standardization of different processes involved in tissue collection. A proper definition of biobanks is large collections of biospecimens linked to relevant personal and health information (health records, family history, lifestyle, genetic information) that are held predominantly for use in health and medical research. In addition, the International Organization for Standardization, in illustrating the requirements for biobanking (ISO 20387:2018), stresses the concept of biobanks being legal entities driving the process of acquisition and storage together with some or all of the activities related to collection, preparation, preservation, testing, analysing and distributing defined biological material as well as related information and data. In this review article, we aim to discuss the basic principles of biobanking, spanning from definitions to classification systems, standardization processes and documents, sustainability and ethical and legal requirements. We also deal with emerging specimens that are currently being generated and shaping the so-called next-generation biobanking, and we provide pragmatic examples of cancer-associated biobanking by discussing the process behind the construction of a biobank and the infrastructures supporting the implementation of biobanking in scientific research.
Original languageUndefined/Unknown
Pages (from-to)233-246
Number of pages14
JournalVirchows Archiv - A Pathological Anatomy and Histopathology
Publication statusPublished - Aug 1 2021


  • Accreditation
  • Biological Specimen Banks
  • classification
  • ethics
  • legislation & jurisprudence
  • standards
  • Biomedical Research
  • Guidelines as Topic
  • Humans
  • Policy Making
  • Precision Medicine
  • Specimen Handling
  • Stakeholder Participation
  • Terminology as Topic
  • Biobanking
  • Biospecimens
  • Cell lines
  • Preanalytical phase
  • Standardization
  • Tissue specimens

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