Basics and frontiers on pancreatic cancer for radiation oncology: Target delineation, SBRT, SIB technique, MRgRT, particle therapy, immunotherapy and clinical guidelines.

Francesco Cellini, Alessandra Arcelli, Nicola Simoni, Luciana Caravatta, Milly Buwenge, Angela Calabrese, Oronzo Brunetti, Domenico Genovesi, Renzo Mazzarotto, Francesco Deodato, Gian Carlo Mattiucci, Nicola Silvestris, Vincenzo Valentini, Alessio Giuseppe Morganti

Research output: Contribution to journalReview articlepeer-review

Abstract

Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on i) the current indications by the available national and international guidelines; ii) the current standard indications for target volume delineation in radiotherapy (RT); iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and vi) a multimodal integration opportunity: the combination of RT with immunotherapy.

Original languageEnglish
Article number1729
Pages (from-to)1-41
Number of pages41
JournalCancers
Volume12
Issue number7
DOIs
Publication statusPublished - Jun 29 2020

Keywords

  • CTV
  • Guidelines
  • Immunotherapy
  • MR guided RT
  • Pancreatic cancer
  • Protons
  • Radiotherapy
  • Review
  • SBRT
  • SIB

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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