Utilizzo del test di attivazione dei basofili (BAT) nella sorveglianza sanitaria di lavoratori esposti a beta - Lattamici e ad intermedi di produzione

Translated title of the contribution: Basophil activation test (BAT) as a novel method for monitoring occupational exposure to beta - Lactams and intermediates of production

Paolo Marraccini, Patrizia Pignatti, Cosimo Cafforio, Marco Emilio Prini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cutaneous tests and specific IgE are used in the diagnosis of allergy due to beta - lactams, although drug administration at therapeutic dosage is considered gold standard in drug allergy. Objectives: The diagnostic approach in symptomatic workers is more critical when they are exposed because of work, unlike reactions to drug in case of therapy. There is not a general consensus about markers in workers occupationally exposed to drugs. Indeed, basophil activation test (BAT) is a new and promising laboratory tool, particularly useful to test intermediate molecules involved in the production. In this article we show our experience on the health surveillance of workers exposed to beta lactams and intermediate molecule (7-ZACA) in a pharmaceutical industry. Methods: We studied 15 workers divided into 3 groups: 5 exposed and symptomatic (group A), 5 exposed and asymptomatic (group B), 5 non exposed and asymptomatic (group C). Results. BAT was positive for 7-ZACA in three subjects of group A, and in one subject of group B and one of group C. There was e concordance between clinical history, respiratory symptoms, and results of texts. It was possible to determine allergic nature of symptoms and sensitization in a preclinical phase, correctly discriminating symptoms related to irritants from theallergic ones. Conclusions. BAT, a simple and quick diagnostic procedure if compared to challenge, can be used as a useful and practical tool by occupational doctors forprevenuon measures, evaluation of ability to a specific job and. reallocation of workers.

Translated title of the contributionBasophil activation test (BAT) as a novel method for monitoring occupational exposure to beta - Lactams and intermediates of production
Original languageItalian
Pages (from-to)79-82
Number of pages4
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume38
Issue number2
Publication statusPublished - Apr 1 2016

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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