Liver cancer is still a major public health problem worldwide. It is now known that solid tumors, including hepatocellular carcinoma, are infiltrated by immune cells most prominently T and B lymphocytes. All of them are variably scattered within the tumor and loaded with an assorted array of cytokines, chemokines, and inflammatory and cytotoxic mediators. This complex network reflects the diversity in tumor biology and tumor-host interactions. Basophil granulocytes and mast cells are well established effector cells in IgE-associated immune responses. While in allergies or parasitic infections the role of these cells has been known for years, in cancer there are what seem to be conflicting data describing a supporting or a possibly inhibitory role of these cells in several human neoplasia. Here, these knowledge will summarize, focusing on the implications of these findings in the understanding the role of basophil granulocytes and mast cells in primary and secondary liver cancer.
|Title of host publication||Basophil Granulocytes|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||17|
|Publication status||Published - 2011|
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