BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT

I. S. Piras, A. Angius, M. Andreani, M. Testi, G. Lucarelli, M. Floris, S. Marktel, F. Ciceri, G. L. La Nasa, K. Fleischhauer, M. G. Roncarolo, A. Bulfone, S. Gregori, R. Bacchetta

Research output: Contribution to journalArticlepeer-review

Abstract

The genetic background of donor and recipient is an important factor determining the outcome of allogeneic hematopoietic SCT (allo-HSCT). We applied whole-genome analysis to investigate genetic variants - other than HLA class I and II - associated with negative outcome after HLA-identical sibling allo-HSCT in a cohort of 110 β-Thalassemic patients. We identified two single-nucleotide polymorphisms (SNPs) in BAT2 (A/G) and BAT3 (T/C) genes, SNP rs11538264 and SNP rs10484558, both located in the HLA class III region, in strong linkage disequilibrium between each other (R2 =0.92). When considered as single SNP, none of them reached a significant association with graft rejection (nominal P-8; and adjusted P=0.0071). The BAT2/BAT3 polymorphisms and specifically the A/C haplotype may represent a novel immunogenetic factor associated with graft rejection in patients undergoing allo-HSCT.

Original languageEnglish
Pages (from-to)1400-1404
Number of pages5
JournalBone Marrow Transplantation
Volume49
Issue number11
DOIs
Publication statusPublished - Nov 13 2014

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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