Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages

M. B. Santucci, A. Ciaramella, M. Mattei, T. Sumerska, M. Fraziano

Research output: Contribution to journalArticle

Abstract

In this study, we report evidences that Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94). In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis and the downmodulation of membrane CD14 expression. Moreover, the addition of broad spectrum matrix metalloproteinase inhibitor to cell culture, during MTB infection, decreases the release of soluble TNF-α and leads to a simultaneous increase of membrane TNF-α. These results show that MTB-induced apoptosis in macrophages is reduced by a MMP inhibitor and most probably is related to TNF-α release. This identifies BB-94 as a simultaneous anti-apoptotic and anti-inflammatory molecule during MTB infection.

Original languageEnglish
Pages (from-to)1657-1665
Number of pages9
JournalInternational Immunopharmacology
Volume3
Issue number12
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Apoptosis
  • Metalloproteinases
  • Monocytes/macrophages
  • MTB infection
  • TNF-α

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Fingerprint Dive into the research topics of 'Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages'. Together they form a unique fingerprint.

  • Cite this

    Santucci, M. B., Ciaramella, A., Mattei, M., Sumerska, T., & Fraziano, M. (2003). Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages. International Immunopharmacology, 3(12), 1657-1665. https://doi.org/10.1016/S1567-5769(03)00202-9