Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages

M. B. Santucci, A. Ciaramella, M. Mattei, T. Sumerska, M. Fraziano

Research output: Contribution to journalArticlepeer-review


In this study, we report evidences that Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94). In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis and the downmodulation of membrane CD14 expression. Moreover, the addition of broad spectrum matrix metalloproteinase inhibitor to cell culture, during MTB infection, decreases the release of soluble TNF-α and leads to a simultaneous increase of membrane TNF-α. These results show that MTB-induced apoptosis in macrophages is reduced by a MMP inhibitor and most probably is related to TNF-α release. This identifies BB-94 as a simultaneous anti-apoptotic and anti-inflammatory molecule during MTB infection.

Original languageEnglish
Pages (from-to)1657-1665
Number of pages9
JournalInternational Immunopharmacology
Issue number12
Publication statusPublished - Nov 2003


  • Apoptosis
  • Metalloproteinases
  • Monocytes/macrophages
  • MTB infection
  • TNF-α

ASJC Scopus subject areas

  • Immunology
  • Pharmacology


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