L'occlusione permanente bilaterale delle carotidi (BCAO) nel ratto causa iperfosforilazione della proteina tau nell'ippocampo

Translated title of the contribution: BCAO induces hyperphosphorilation of tau protein in the hippocampus

Marilena Mangiardi, Carla L. Busceti, Francesca Biagioni, Federica Mastroiacovo, Francesco Orzi

Research output: Contribution to journalArticle

Abstract

There is evidence from studies of epidemiology, pharmacology, neuroimaging, clinical medicine, microscopic anatomy and cellular-molecular biology to suggest that sporadic Alzheimer Disease (AD) is a vascular disorder caused by impaired cerebral perfusion. The consensus of these studies indicates that chronic brain hypoperfusion can be included among the risk factors leading to the development of AD. In this study we check if the chronic brain hypoperfusion in rat, induces histopathological hallmarks changes, similar to those commonly found in AD.

Original languageItalian
Pages (from-to)261-267
Number of pages7
JournalRivista Italiana di Neurobiologia
Volume4
Issue number3-4
Publication statusPublished - 2007

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tau Proteins
Hippocampus
Alzheimer Disease
Clinical Medicine
Brain
Neuroimaging
Blood Vessels
Cell Biology
Molecular Biology
Anatomy
Consensus
Epidemiology
Perfusion
Pharmacology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

L'occlusione permanente bilaterale delle carotidi (BCAO) nel ratto causa iperfosforilazione della proteina tau nell'ippocampo. / Mangiardi, Marilena; Busceti, Carla L.; Biagioni, Francesca; Mastroiacovo, Federica; Orzi, Francesco.

In: Rivista Italiana di Neurobiologia, Vol. 4, No. 3-4, 2007, p. 261-267.

Research output: Contribution to journalArticle

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