L'occlusione permanente bilaterale delle carotidi (BCAO) nel ratto causa iperfosforilazione della proteina tau nell'ippocampo

Translated title of the contribution: BCAO induces hyperphosphorilation of tau protein in the hippocampus

Marilena Mangiardi, Carla L. Busceti, Francesca Biagioni, Federica Mastroiacovo, Francesco Orzi

Research output: Contribution to journalArticlepeer-review


There is evidence from studies of epidemiology, pharmacology, neuroimaging, clinical medicine, microscopic anatomy and cellular-molecular biology to suggest that sporadic Alzheimer Disease (AD) is a vascular disorder caused by impaired cerebral perfusion. The consensus of these studies indicates that chronic brain hypoperfusion can be included among the risk factors leading to the development of AD. In this study we check if the chronic brain hypoperfusion in rat, induces histopathological hallmarks changes, similar to those commonly found in AD.

Translated title of the contributionBCAO induces hyperphosphorilation of tau protein in the hippocampus
Original languageItalian
Pages (from-to)261-267
Number of pages7
JournalRivista Italiana di Neurobiologia
Issue number3-4
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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