There is evidence from studies of epidemiology, pharmacology, neuroimaging, clinical medicine, microscopic anatomy and cellular-molecular biology to suggest that sporadic Alzheimer Disease (AD) is a vascular disorder caused by impaired cerebral perfusion. The consensus of these studies indicates that chronic brain hypoperfusion can be included among the risk factors leading to the development of AD. In this study we check if the chronic brain hypoperfusion in rat, induces histopathological hallmarks changes, similar to those commonly found in AD.
|Translated title of the contribution||BCAO induces hyperphosphorilation of tau protein in the hippocampus|
|Number of pages||7|
|Journal||Rivista Italiana di Neurobiologia|
|Publication status||Published - 2007|
ASJC Scopus subject areas
- Clinical Neurology