Bcl-2 and Bax are involved in the sympathetic protection of brown adipocytes from obesity-linked apoptosis

Luca Briscini, Cristina Tonello, Laura Dioni, Michele O. Carruba, Enzo Nisoli

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Obesity is linked to functional brown adipose tissue (BAT) atrophy, partially due to adipocyte apoptosis. The brown adipocytes of obese rats have lower Bcl-2/Bax mRNA and protein ratios than those of their lean littermates. Exposure to a low temperature for three days markedly increased the Bcl-2/Bax ratio, by increasing the noradrenergic output to BAT, which has previously been shown to reduce apoptotic cell death. This effect could be mimicked in vitro by the addition of noradrenaline (NA) to brown adipocytes differentiated in culture. Micromolar NA concentrations increased the Bcl-2/Bax mRNA and protein ratios, and protected against serum deprivation-induced apoptosis. We conclude that NA acts by modulating bcl-2 and bax gene expression.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalFEBS Letters
Volume431
Issue number1
DOIs
Publication statusPublished - Jul 10 1998

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Brown Adipocytes
bcl-2-Associated X Protein
Norepinephrine
Brown Adipose Tissue
Obesity
Apoptosis
Tissue
bcl-2 Genes
Messenger RNA
Cell death
Adipocytes
Gene expression
Atrophy
Rats
Proteins
Cell Death
Gene Expression
Temperature
Serum

Keywords

  • Bax
  • Bcl02
  • Brown fat
  • Obesity
  • Sympathetic activity

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Bcl-2 and Bax are involved in the sympathetic protection of brown adipocytes from obesity-linked apoptosis. / Briscini, Luca; Tonello, Cristina; Dioni, Laura; Carruba, Michele O.; Nisoli, Enzo.

In: FEBS Letters, Vol. 431, No. 1, 10.07.1998, p. 80-84.

Research output: Contribution to journalArticle

Briscini, Luca ; Tonello, Cristina ; Dioni, Laura ; Carruba, Michele O. ; Nisoli, Enzo. / Bcl-2 and Bax are involved in the sympathetic protection of brown adipocytes from obesity-linked apoptosis. In: FEBS Letters. 1998 ; Vol. 431, No. 1. pp. 80-84.
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