BCL-6 gene mutations in primary cutaneous B-cell lymphomas

Research output: Contribution to journalArticle

Abstract

We analyzed mutations in the 5′ non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.

Original languageEnglish
Pages (from-to)624-626
Number of pages3
JournalHaematologica
Volume89
Issue number5
Publication statusPublished - May 2004

Fingerprint

B-Cell Lymphoma
Skin
Mutation
Mutation Rate
Genes
B-Lymphocytes
Polymerase Chain Reaction
Neoplasms

Keywords

  • BCL-6 gene
  • BCL-6 mutations
  • Cutaneous lymphoma
  • Extranodal non-Hodgkin's lymphoma
  • Primary cutaneous B-cell lymphomas

ASJC Scopus subject areas

  • Hematology

Cite this

BCL-6 gene mutations in primary cutaneous B-cell lymphomas. / Gianelli, Umberto; Cerri, Amilcare; Cassani, Barbara; Moneghini, Laura; Raviele, Paola Rafaniello; Berti, Emilio; Bosari, Silvano.

In: Haematologica, Vol. 89, No. 5, 05.2004, p. 624-626.

Research output: Contribution to journalArticle

@article{bd1d068ff54b46e29f931f4804a7175a,
title = "BCL-6 gene mutations in primary cutaneous B-cell lymphomas",
abstract = "We analyzed mutations in the 5′ non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.",
keywords = "BCL-6 gene, BCL-6 mutations, Cutaneous lymphoma, Extranodal non-Hodgkin's lymphoma, Primary cutaneous B-cell lymphomas",
author = "Umberto Gianelli and Amilcare Cerri and Barbara Cassani and Laura Moneghini and Raviele, {Paola Rafaniello} and Emilio Berti and Silvano Bosari",
year = "2004",
month = "5",
language = "English",
volume = "89",
pages = "624--626",
journal = "Haematologica",
issn = "0390-6078",
publisher = "NLM (Medline)",
number = "5",

}

TY - JOUR

T1 - BCL-6 gene mutations in primary cutaneous B-cell lymphomas

AU - Gianelli, Umberto

AU - Cerri, Amilcare

AU - Cassani, Barbara

AU - Moneghini, Laura

AU - Raviele, Paola Rafaniello

AU - Berti, Emilio

AU - Bosari, Silvano

PY - 2004/5

Y1 - 2004/5

N2 - We analyzed mutations in the 5′ non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.

AB - We analyzed mutations in the 5′ non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.

KW - BCL-6 gene

KW - BCL-6 mutations

KW - Cutaneous lymphoma

KW - Extranodal non-Hodgkin's lymphoma

KW - Primary cutaneous B-cell lymphomas

UR - http://www.scopus.com/inward/record.url?scp=2542479950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542479950&partnerID=8YFLogxK

M3 - Article

C2 - 15136235

AN - SCOPUS:2542479950

VL - 89

SP - 624

EP - 626

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 5

ER -