BCL10 gene mutations rarely occur in lymphoid malignancies

S. Luminari, D. Intini, L. Baldini, E. Berti, F. Bertoni, E. Zucca, L. Cro, A. T. Maiolo, F. Cavalli, A. Neri

Research output: Contribution to journalArticle

Abstract

BCL10, a gene involved in apoptosis signalling, has recently been identified through the cloning of chromosomal breakpoints in extranodal (MALT-type) marginal zone lymphomas carrying the t(1;14)(p22;q32) translocation. BCL10 was also found mutated in these cases as well as in other types of lymphoid and solid tumors, suggesting that its inactivation may play an important pathogenetic role; however, this has been questioned by recent studies showing a lack of somatic mutations in human cancers. We report the mutation analysis of exons 1-3 of the BCL10 gene in DNAs from 228 cases of lymphoid malignancies (30 B cell chronic lymphocytic leukemias, 123 B and 45 T non-Hodgkin's lymphomas and 30 multiple myelomas). Somatic mutations were detected in four cases (2%): one small lymphocytic, one follicular and two diffuse large cell lymphomas. The mutations were all within exon 3 and have not been previously reported. Our data suggest that BCL10 mutations may play only a limited role in the pathogenesis of lymphoid neoplasms.

Original languageEnglish
Pages (from-to)905-908
Number of pages4
JournalLeukemia
Volume14
Issue number5
Publication statusPublished - 2000

Keywords

  • BCL10
  • Multiple myeloma
  • Mutation analysis
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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    Luminari, S., Intini, D., Baldini, L., Berti, E., Bertoni, F., Zucca, E., Cro, L., Maiolo, A. T., Cavalli, F., & Neri, A. (2000). BCL10 gene mutations rarely occur in lymphoid malignancies. Leukemia, 14(5), 905-908.