BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma

Kenneth Offit, Diane C. Louie, Nasser Z. Parsa, Pampa Roy, Denis Leung, Francesco Lo Coco, Andrew Zelenetz, Riccardo Dalla-Favera, R. S K Chaganti

Research output: Contribution to journalArticlepeer-review

Abstract

Evidence for rearrangement of the BCL6 gene at 3q27 has been documented in 20-30% of diffuse lymphomas with a large cell component (DLLC), and was found to be of prognostic significance at the time of diagnosis. To incorporate these observations into current cytogenetic and clinical prognostic models, 76 cases of DLLC with known BCL6 status were analyzed. Cytogenetic indicators of progression, including trisomy 7, trisomy 12, del(6)(q21q25), and structural alterations of 17p were less frequent in BCL6 rearranged DLLC compared to BCL6 germline tumors. Despite a 93% overall survival at median follow-up of 30 months, a trend for continued relapse resulted in a projected freedom from progression for the BCL6 rearranged cohort of 66% at 4 years, compared to 39% for the BCL6 germline cohort. Six cases among the BCL6 rearranged group lacked additional cytogenetic indicators of progression and remained free of disease at follow-up in excess of 7 years, whereas BCL6 rearranged cases with increasing numbers of cytogenetic aberrations showed decreased intervals free from progression of disease. These results suggest that BCL6 rearrangement should be combined with other known clinical and cytogenetic indicators in prognostic analyses of patients with DLLC.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalLeukemia and Lymphoma
Volume20
Issue number1-2
DOIs
Publication statusPublished - 1995

Keywords

  • Chromosome 3
  • Cytogenetics
  • Non-Hodgkin's lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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