BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice

F. Fumagalli, G. Racagni, E. Colombo, M. A. Riva

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

BDNF is an important regulator of brain development and plasticity, and changes in its expression can be associated to neuropsychiatric disorders. Since dysregulation of dopamine transmission is considered central to these conditions, the authors investigated BDNF expression in dopamine transporter knockout mice (DAT-/-). They demonstrate that altered homeostasis of the dopaminergic system drastically reduces BDNF expression in the frontal cortex during development and adulthood. These results suggest that dopamine-BDNF interaction might be relevant for the impairment in synaptic plasticity associated to neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)898-899+893
JournalMolecular Psychiatry
Volume8
Issue number11
DOIs
Publication statusPublished - 2003

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Dopamine Plasma Membrane Transport Proteins
Brain-Derived Neurotrophic Factor
Frontal Lobe
Knockout Mice
Gene Expression
Dopamine
Neuronal Plasticity
Homeostasis
Brain

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health

Cite this

BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice. / Fumagalli, F.; Racagni, G.; Colombo, E.; Riva, M. A.

In: Molecular Psychiatry, Vol. 8, No. 11, 2003, p. 898-899+893.

Research output: Contribution to journalArticle

Fumagalli, F. ; Racagni, G. ; Colombo, E. ; Riva, M. A. / BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice. In: Molecular Psychiatry. 2003 ; Vol. 8, No. 11. pp. 898-899+893.
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