BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

G. Spalletta, D. W. Morris, F. Angelucci, I. A. Rubino, I. Spoletini, P. Bria, G. Martinotti, A. Siracusano, G. Bonaviri, S. Bernardini, C. Caltagirone, P. Bossù, G. Donohoe, M. Gill, A. P. Corvin

Research output: Contribution to journalArticle

Abstract

Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalEuropean Psychiatry
Volume25
Issue number6
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Aggression
  • BDNF
  • Polymorphism
  • Schizophrenia
  • Val66Met

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Spalletta, G., Morris, D. W., Angelucci, F., Rubino, I. A., Spoletini, I., Bria, P., Martinotti, G., Siracusano, A., Bonaviri, G., Bernardini, S., Caltagirone, C., Bossù, P., Donohoe, G., Gill, M., & Corvin, A. P. (2010). BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia. European Psychiatry, 25(6), 311-313. https://doi.org/10.1016/j.eurpsy.2009.10.008