Beat-to-beat analysis of left ventricular pressure-volume relation and stroke volume by conductance catheter and aortic modelflow in cardiomyoplasty patients

J. J. Schreuder, F. H. Van der Veen, E. T. Van der Velde, F. Delahaye, O. Alfieri, O. Jegaden, R. Lorusso, J. R C Jansen, V. Van Ommen, G. Finet, H. J J Wellens

Research output: Contribution to journalArticle

Abstract

Background: Since the clinical introduction of dynamic cardiomyoplasty, a discrepancy has been observed between unchanged measurements of cardiac function and improved clinical outcome. Methods and Results: We performed a beat-to-beat analysis of cardiac performance at rest in nine cardiomyoplasty patients 6 to 24 months after operation. Conductance and micromanometer catheters were placed in left ventricle and aorta and used for measurements over a 15-second period, during which the wrapped latissimus dorsi (LD) muscle was stimulated for 10 seconds in a 1:2 synchronization mode followed by a 5-second period without LD stimulation. The synchronization delay between start of the QRS complex and the LD contraction was changed from 4 up to 125 ms at the patient's clinical stimulation strength and at an increased supramaximal amplitude. Comparing the LD assisted period to the unassisted period, at the clinical settings no significant changes in stroke volume (SV) as measured by the conductance technique and the aortic Modelflow technique were observed. A significant (P

Original languageEnglish
Pages (from-to)2010-2017
Number of pages8
JournalCirculation
Volume91
Issue number7
Publication statusPublished - 1995

Keywords

  • diastole
  • electrophysiology
  • pressure
  • stroke volume
  • ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Schreuder, J. J., Van der Veen, F. H., Van der Velde, E. T., Delahaye, F., Alfieri, O., Jegaden, O., Lorusso, R., Jansen, J. R. C., Van Ommen, V., Finet, G., & Wellens, H. J. J. (1995). Beat-to-beat analysis of left ventricular pressure-volume relation and stroke volume by conductance catheter and aortic modelflow in cardiomyoplasty patients. Circulation, 91(7), 2010-2017.